Biochemical Genetics

, Volume 51, Issue 5–6, pp 398–405 | Cite as

Association Between Apolipoprotein E Gene Polymorphism and Myocardial Infarction

  • Parthasaradhireddy Tanguturi
  • Bhoomireddy Pullareddy
  • P. Sampath Kumar
  • Dwarkanath K. Murthy
Article
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Accepted:

Abstract

We investigated apolipoprotein E (APOE) genotypic influence on myocardial infarction risk in South India, where the disease is emerging as a major threat to the public health care system. The study included 412 subjects: 202 myocardial infarction patients and 210 age- and sex-matched controls. DNA was isolated, the polymorphism of the APOE gene was subjected to PCR, and lipid levels were evaluated. The prevalence of E3/E4 genotypes in patients (18.3%) was 1.5-fold that of controls (11.0%, p < 0.05), and the prevalence of E2/E3 genotypes was higher in controls (6.7%) than in patients (4%). The ε4 allele was significantly associated with myocardial infarction: χ 2 = 12.4; OR 2.2 (CI 95%: 1.4–3.4), p < 0.004, for ε4 versus ε3 and χ 2 = 5.7; OR 2.7 (CI 95%: 1.1–6.5), p > 0.01, for ε4 versus ε2. A significant association of the ε4 allele, especially the E3/E4 genotype, with myocardial infarction was observed.

Keywords

Myocardial infarction Apolipoprotein E polymorphism Cardiovascular disease 
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Notes

Acknowledgments

The authors thank the patients and their families for their valuable contribution. The authors also thank Mr. N. Bala Krishna for the statistical analysis.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Parthasaradhireddy Tanguturi
    • 1
  • Bhoomireddy Pullareddy
    • 2
  • P. Sampath Kumar
    • 3
  • Dwarkanath K. Murthy
    • 1
  1. 1.Department of GeneticsOsmania UniversityHyderabadIndia
  2. 2.Department of Cell and Molecular BiologyInstitute of Genetics and Hospital for Genetic DiseasesHyderabadIndia
  3. 3.Cardiology DepartmentOsmania General HospitalHyderabadIndia

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