Biochemical Genetics

, Volume 50, Issue 3–4, pp 298–308 | Cite as

Association of Hepatocyte Nuclear Factor 4 Alpha Polymorphisms with Type 2 Diabetes With or Without Metabolic Syndrome in Malaysia

  • Riyadh Saif-Ali
  • Roslan Harun
  • Nor Azmi Kamaruddin
  • Saad Al-Jassabi
  • Wan Zurinah Wan Ngah
Article
  • 185 Downloads

Abstract

This study investigated the association of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) with type 2 diabetes with or without metabolic syndrome in Malaysia. Nine HNF4 alpha SNPs were genotyped in 390 type 2 diabetic subjects with metabolic syndrome, 135 type 2 diabetic subjects without metabolic syndrome, and 160 control subjects. The SNPs rs4810424, rs1884613, and rs2144908 were associated with protection against type 2 diabetes without metabolic syndrome (recessive P = 0.018, OR 0.32; P = 0.004, OR 0.25; P = 0.005, OR 0.24, respectively). The 6-SNP haplotype2 CCCGTC containing the risk genotype of these SNPs was associated with higher risk for type 2 diabetes with or without metabolic syndrome (P = 0.002, OR 2.2; P = 0.004, OR 3.1). These data suggest that HNF4 alpha SNPs and haplotypes contributed to increased type 2 diabetes risk in the Malaysian population.

Keywords

Hepatocyte nuclear factor 4 alpha Type 2 diabetes Metabolic syndrome Single nucleotide polymorphisms Haplotype 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Riyadh Saif-Ali
    • 1
    • 2
  • Roslan Harun
    • 3
    • 4
  • Nor Azmi Kamaruddin
    • 3
  • Saad Al-Jassabi
    • 5
  • Wan Zurinah Wan Ngah
    • 3
    • 4
  1. 1.Department of Molecular Medicine, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia
  2. 2.Faculty of MedicineSana’a UniversitySana’aYemen
  3. 3.UKM Medical CenterUniversity Kebangsaan MalaysiaKuala LumpurMalaysia
  4. 4.UKM Medical Molecular Biology Institute (UMBI)University Kebangsaan MalaysiaKuala LumpurMalaysia
  5. 5.Institute of Biological ScienceUniversity of MalayaKuala LumpurMalaysia

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