Biochemical Genetics

, Volume 50, Issue 3–4, pp 277–284 | Cite as

Prion Protein Coding Gene (PRNP) Variability in Sheep from Turkey and Iran

  • Fateme Frootan
  • Gholamreza Nikbakht
  • Nehir Özdemir Özgentürk
  • Cemal Ün


This study was designed to analyze variation of ovine prion protein in sheep breeds in Iran and Turkey. A competitive approach was used to analyze the open reading frame (ORF) of the ovine PRNP gene using a total of 186 samples from five indigenous sheep breeds. The ARQ allele was found to be the predominant allele in five breeds. The ARR allele was not observed in homozygous combination among the 11 genotypes found in the study. In addition, six other polymorphisms were indicated. These findings have great significance for estimating genetic variability in the PRNP gene with regard to Iranian and Turkish sheep. Since no information on the susceptibility of some genotypes identified in this study has been reported, no grouping was made on the basis of susceptibility.


Gene variation Prion gene Iranian sheep Turkish sheep 



This study was supported by the Research Fund of the Yıldız Technical University, Project No. 27-01-07-01. The authors would like to thank Assoc. Prof. Dr. Kemal Öztabak for his support during the study.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Fateme Frootan
    • 1
  • Gholamreza Nikbakht
    • 2
  • Nehir Özdemir Özgentürk
    • 1
  • Cemal Ün
    • 3
  1. 1.Department of Biology, Faculty of Science and ArtsYıldız Technical UniversityMerter, IstanbulTurkey
  2. 2.Department of Microbiology and Immunology, Faculty of Veterinary MedicineUniversity of TehranTehranIran
  3. 3.Department of Biology, Faculty of ScienceEge UniversityIzmirTurkey

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