Biochemical Genetics

, Volume 48, Issue 1–2, pp 26–33

A Decreasing Gradient of 374F Allele Frequencies in the Skin Pigmentation Gene SLC45A2, from the North of West Europe to North Africa

  • Gérard Lucotte
  • Géraldine Mercier
  • Florent Diéterlen
  • Isao Yuasa
Article

DOI: 10.1007/s10528-009-9289-4

Cite this article as:
Lucotte, G., Mercier, G., Diéterlen, F. et al. Biochem Genet (2010) 48: 26. doi:10.1007/s10528-009-9289-4

Abstract

The 374F mutation in the SLC45A2 gene, encoding the membrane-associated transporter protein (MATP) that plays an important role in melanin synthesis, has been suggested to be associated with skin color in Caucasians. In this study, the detailed distribution of the 374F allele has been investigated in 2063 unrelated subjects from 18 European and three North African populations. The highest allele frequency is observed in Denmark (0.980), and the lowest frequencies are observed in Tunisia (0.610) and in Morocco (0.691). A significant latitudinal cline in 374F allele frequencies was observed, ranging from the north of West Europe to North Africa (r = 0.869). The results confirm that the distribution of the 374F allele may reflect the ultraviolet radiation level and can be associated with skin color variation in these regions.

Keywords

Membrane-associated transporter protein (MATP) Skin pigmentation SLC45A2 gene 374F allele frequencies Population study 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gérard Lucotte
    • 1
  • Géraldine Mercier
    • 1
  • Florent Diéterlen
    • 1
  • Isao Yuasa
    • 2
  1. 1.Institute of Molecular AnthropologyParisFrance
  2. 2.Division of Legal Medicine, Faculty of MedicineTottori UniversityYonagoJapan

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