Regeneration of Articular Cartilage in Experimental Osteoarthrosis after Injection of a Complex Polyacrylamide-Hyaluronic Gel
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The regenerative capacity of articular cartilage was assessed after injection of Matricin polyacrylamide-hyaluronic gel into the knee joints of nine rabbits with a model of osteoarthrosis. Matricin decreased dystrophic and destructive changes in articular cartilage previously induced by exposure to papain solution and produced a significant increase in the regenerative capacity of the damaged hyaline cartilage.
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References
- 1.Clinical Recommendations. Rheumatology [in Russian], Nasonov, E. L. (ed.), GEOTAR-Media, Moscow (2005), pp, 99-111.Google Scholar
- 2.Towheed, T. E., Maxwell, L., Judd, M. G., Catton, M., Hochberg, M. C., and Wells, G., “Acetaminophen for osteoarthritis,” Cochrane Database Syst. Rev., CD004257 (2003).Google Scholar
- 3.Hochberg, M. C. and Clegg, D. O., “Potential effects of chondroitin sulfate on joint swelling: A GAIT report,” Osteoarthr. Cart., 16. Suppl. 3, 22-24 (2008).Google Scholar
- 4.Gerasimenko, A. Yu., Zhurbina, N. N., Kurilova, U. E., Ichkitidze, L. P., Selishchev, S. V., Suetina, I. A., Mezentseva, M. A., Russu, L. I., Zar, V. V., and Podgaetskii, V. M., “Knee joint ligament implants with composite nanocoatings,” Biomed. Eng., 50, No. 3, 206-209 (2016).CrossRefGoogle Scholar
- 5.Brandt, K. D., Mazzuca, S. A., and Katz, B. P., “Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial,” Arthritis Rheum., 52, 2015-2025 (2005).CrossRefGoogle Scholar
- 6.Balazs, E. A. and Denlinger, J. L., “Viscosupplementation: A new concept in the treatment of osteoarthritis,” J. Rheumatol., 39, 3-9 (1993).Google Scholar
- 7.Shekhter, A. B., Zar, V. V., Voloshin, V. P., and Lopatin, V. V., “Tissue and cell reactions of the synovial medium to intraarticu lar administration of the polymer viscoprosthesis Noltrex in experimental conditions,” Al’m. Klin. Med., No. 28, 20-24 (2013).Google Scholar
- 8.Zar, V. V., Voloshin, V. P., and Martynov, M. D., “Functional assessment of the results of intraarticular administration of Noltrex polyacrylamide gel in the treatment of patients with gonarthrosis,” Al’m. Klin. Med., No. 27, 18-24 (2012).Google Scholar
- 9.Lopatin, V. V., Belonenko, V. N., Zar, V. V., and Askadskii, A. A., “Comparative studies of the mechanical behavior of human joint fluid and polyacrylamide hydrogel depending on pressure,” Plast. Massy, No. 7, 24-29 (2004).Google Scholar
- 10.Lopatin, V. V, et al., “Swelling of medical polyacrylamide gels,” Vysokomol. Soedin. Ser. A, No. 7, 1187-1195 (2005).Google Scholar
- 11.Vlasov, V. I., Kuznetsova, E. A., Lopatin, V. I., and Dar’evich, E. N., The Medical Material ‘Matrexin’ Based on Polyacrylamide Gel and Means for Its Preparation (variants), RF Patent 2545806: No. 2013157847/15; April 10, 2015; Byul. No. 10, 1-17.Google Scholar
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