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Biogerontology

, Volume 20, Issue 1, pp 33–48 | Cite as

Metformin as a geroprotector: experimental and clinical evidence

  • Veronika Piskovatska
  • Nadiya Stefanyshyn
  • Kenneth B. Storey
  • Alexander M. VaisermanEmail author
  • Oleh LushchakEmail author
Review Article

Abstract

Apart from being a safe, effective and globally affordable glucose-lowering agent for the treatment of diabetes, metformin has earned much credit in recent years as a potential anti-aging formula. It has been shown to significantly increase lifespan and delay the onset of age-associated decline in several experimental models. The current review summarizes advances in clinical research on the potential role of metformin in the field of geroprotection, highlighting findings from pre-clinical studies on known and putative mechanisms behind its beneficial properties. A growing body of evidence from clinical trials demonstrates that metformin can effectively reduce the risk of many age-related diseases and conditions, including cardiometabolic disorders, neurodegeneration, cancer, chronic inflammation, and frailty. Metformin also holds promise as a drug that could be repurposed for chemoprevention or adjuvant therapy for certain cancer types. Moreover, due to the ability of metformin to induce autophagy by activation of AMPK, it is regarded as a potential hormesis-inducing agent with healthspan-promoting and pro-longevity properties. Long-term intake of metformin is associated with low risk of adverse events; however, well-designed clinical trials are still warranted to enable potential use of this therapeutic agent as a geroprotector.

Keywords

Metformin Age-related disease Longevity Hormesis Model organism Type 2 diabetes Cardiovascular disease Inflammation 

Notes

Acknowledgements

This work was partially supported via a Grant from the Ministry of Education and Science of Ukraine to OL (#0117U006426) and discovery grant from the Natural Sciences and Engineering Research Council of Canada (#6793) to KBS.

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© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Clinic for Heart SurgeryUniversity Clinic of the Martin Luther UniversityHalleGermany
  2. 2.Department of Biochemistry and BiotechnologyVasyl Stefanyk Precarpathian National UniversityIvano-FrankivskUkraine
  3. 3.Institute of BiochemistryCarleton UniversityOttawaCanada
  4. 4.D.F. Chebotarev Institute of GerontologyNAMSKievUkraine

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