The somatotropic axis may not modulate ageing and longevity in humans
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Studies in nematodes and mice have shown that the somatotropic axis can modulate their longevity and it has been argued that it could also modulate human longevity. Thus, like nematodes and mice, human beings should live longer when facing starvation and genetic variation of the somatotropic axis should be linked to longevity. This article argues that, because the life-history strategies of humans are very different from those of mice, these hypotheses are not warranted.
KeywordsSomatotropic axis IGF-1 Growth hormone Life history strategies Longevity Ageing
Many thanks are due to Simon Galas, University of Montpellier, France, and to anonymous referees for their helpful comments.
- Aguiar-Oliveira MH, Oliveira FT, Pereira RM, Oliveira CR, Black- ford A, Valenca EH, Santos EG, Gois-Junior MB, Meneguz-Moreno RA, Araujo VP, Oliveira-Neto LA, Almeida RP, Santos MA, Farias NT, Silveira DC, Cabral GW, Calazans FR, Seabra JD, Lopes TF, Rodrigues EO, Porto LA, Oliveira IP, Melo EV, Martari M, Salvatori R (2010) Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene. J Clin Endocrinol Metab 95:714–721CrossRefPubMedPubMedCentralGoogle Scholar
- Bertrand HA, Herlihy JT, Ikeno Y, Yu BP (1999) Dietary restriction. In: Yu BP (ed) Methods in Aging Research. CRC Press, Boca Raton, pp 271–300Google Scholar
- Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489:318–321CrossRefPubMedGoogle Scholar
- Nygaard M, Lindahl-Jacobsen R, Soerensen M, Mengel-From J, Andersen-Ranberg K, Jeune B, Vaupel JW, Tan Q, Christiansen L, Christensen K (2014) Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals. Exp Gerontol 57:41–46CrossRefPubMedGoogle Scholar
- Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Jacobsen R, Suchiman HE, de Craen AJ, Westendorp RG, Schreiber S, Stevnsner T, Bohr VA, Slagboom PE, Nebel A, Vaupel JW, Christensen K, McGue M, Christiansen L (2012) Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Exp Gerontol 47:379–387CrossRefPubMedPubMedCentralGoogle Scholar
- Wade N (2009) Dieting monkeys offer hope for living longer. New York Times, New York edition, page A1. http://www.nytimes.com/2009/07/10/science/10aging.html