, Volume 17, Issue 2, pp 421–429 | Cite as

The somatotropic axis may not modulate ageing and longevity in humans

  • Éric Le BourgEmail author
Opinion Article


Studies in nematodes and mice have shown that the somatotropic axis can modulate their longevity and it has been argued that it could also modulate human longevity. Thus, like nematodes and mice, human beings should live longer when facing starvation and genetic variation of the somatotropic axis should be linked to longevity. This article argues that, because the life-history strategies of humans are very different from those of mice, these hypotheses are not warranted.


Somatotropic axis IGF-1 Growth hormone Life history strategies Longevity Ageing 



Many thanks are due to Simon Galas, University of Montpellier, France, and to anonymous referees for their helpful comments.


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Centre de Recherches sur la Cognition Animale, Centre de Biologie IntégrativeUniversité de Toulouse, CNRS, UPSToulouseFrance

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