Biogerontology

, Volume 14, Issue 6, pp 719–727 | Cite as

Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study

  • Liljana Gentschew
  • Friederike Flachsbart
  • Rabea Kleindorp
  • Nandini Badarinarayan
  • Stefan Schreiber
  • Almut Nebel
Research Article

Abstract

The role of superoxide dismutases (SODs) in aging and oxidative stress regulation has been widely studied and there is growing evidence that imbalances in these processes influence lifespan in several species. In humans, genetic polymorphisms in SOD genes may play an important role in the development of age-related diseases and genetic variation in SOD2 is thought to be associated with longevity. These observations prompted us to perform a case–control association study using a comprehensive haplotype tagging approach for the three SOD genes (SOD1, SOD2, SOD3) by testing a total of 19 SNPs in our extensive collection of 1,612 long-lived individuals (centenarians and nonagenarians) and 1,104 younger controls. Furthermore, we intended to replicate the previous association of the SOD2 SNP rs4880 with longevity observed in a Danish cohort. In our study, no association was detected between the tested SNPs and the longevity phenotype, neither in the entire long-lived sample set nor in the centenarian subgroup analysis. Our results suggest that there is no considerable influence of sequence variation in the SOD genes on human longevity in Germans.

Keywords

SOD Aging Centenarians SNP Case–control association 

Notes

Acknowledgments

This study was funded by the DFG Excellence Cluster ‘Inflammation at Interfaces’, the INTERREG 4 A programme Syddanmark-Schleswig-K.E.R.N (with EU funds from the European Regional Development Fund) and the RESOLVE project (FP7-HEALTH-F4-2008-202047).

Supplementary material

10522_2013_9470_MOESM1_ESM.doc (494 kb)
Supplementary material 1 (DOC 494 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Liljana Gentschew
    • 1
  • Friederike Flachsbart
    • 1
  • Rabea Kleindorp
    • 1
  • Nandini Badarinarayan
    • 1
  • Stefan Schreiber
    • 1
    • 2
    • 3
  • Almut Nebel
    • 1
  1. 1.Institute of Clinical Molecular BiologyChristian-Albrechts-University of KielKielGermany
  2. 2.Clinic for Internal Medicine IUniversity Hospital Schleswig-HolsteinKielGermany
  3. 3.Popgen BiobankChristian-Albrechts-UniversityKielGermany

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