Progeroid syndromes: models for stem cell aging?
Stem cells are responsible for tissue repair and maintenance and it is assumed that changes observed in the stem cell compartment with age underlie the concomitant decline in tissue function. Studies in murine models have highlighted the importance of intrinsic changes occurring in stem cells with age. They have also drawn the attention to other factors, such as changes in the local or systemic environment as the primary cause of stem cell dysfunction. Whilst knowledge in murine models has been advancing rapidly there has been little translation of these data to human aging. This is most likely due to the difficulties of testing the regenerative capacity of human stem cells in vivo and to substantial differences in the aging phenotype within humans. Here we summarize evidence to show how progeroid syndromes, integrated with other models, can be valuable tools in addressing questions about the role of stem cell aging in human degenerative diseases of older age and the molecular pathways involved.
KeywordsDown syndrome Notch Wnt Hematopoietic Mesenchymal System biology
- Gambardella A, Nagaraju CK et al (2011) Glycogen synthase kinase-3alpha/beta inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage. J Bone Miner Res 26(4):811–821PubMedCrossRefGoogle Scholar
- Waterstrat A, Oakley E, Miller A, Swierski C, Liang Y, Van Zant G (2008) Mechanisms of stem cell aging. In: Rudolph KL (ed) Telomeres and telomerase in ageing, disease, and cancer, Springer, pp 111–140Google Scholar