Biogerontology

, Volume 12, Issue 1, pp 31–35 | Cite as

Biogerontology in the Czech Republic

Review Article

Abstract

Authors provide results of their review of research in the field of biogerontology. Despite the fact that the term “biogerontology” is not commonly used in Czech scientific practice, there have been many research efforts in this field. Up to present, the Czech research teams have focused on the theoretical and biological models of ageing, its immunological aspects, the risk factors of unsuccessfull human ageing, and also metabolic and nutritional factors. Many research teams are dealing with the mechanisms of the neurodegeneration. The authors conclude that better coordination and systematic funding of research in gerontology is needed because of the actual demographic challenges.

Keywords

Ageing Gerontology Senescence Degeneration Alzheimer′s disease Age-related diseases 

References

  1. Arking DE, Krebsova A, Macek M Sr, Macek M Jr, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC (2002) Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA 99(2):856–861PubMedCrossRefGoogle Scholar
  2. Bartek J, Hodný Z, Lukás J (2009) Cytokine loops driving senescence. Nat Cell Biol 10:8Google Scholar
  3. Buckiova D, Popelar J, Syka J (2007) Aging cochleas in the F344 rat: morphological and functional changes. Exp Gerontol 42(7):629–638PubMedCrossRefGoogle Scholar
  4. Burianova J, Ouda L, Profant O, Syka J (2009) Age-related changes in GAD levels in the central auditory system of the rat. Exp Gerontol 44(3):161–169PubMedCrossRefGoogle Scholar
  5. Cejková J, Vejrazka M, Pláteník J, Stípek S (2004) Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea. Exp Gerontol 39(10):1537–1543PubMedCrossRefGoogle Scholar
  6. Chvátal A, Anderová M, Neprasová H et al (2008) Pathological potential of astroglia. Physiol Res 57: S101–S110Google Scholar
  7. Deyl Z, Juricová M, Rosmus J, Adam M (1971) Aging of the connective tissue:collagen cross linking in animals of different species and equal age. Exp Gerontol 6(3):227–233PubMedCrossRefGoogle Scholar
  8. Doubal S (1982) Theory of reliability, biological systems and aging. Mech Ageing Dev 18:349–353CrossRefGoogle Scholar
  9. Doubal S, Klemera P (1990) Influence of aging rate changes on mortality curves. Mech Ageing Dev 54:75–85PubMedCrossRefGoogle Scholar
  10. Doubal S, Klemera P (1999a) The effect of antioxidants and dietary restriction on mortality curves. AGE 22:101–105CrossRefGoogle Scholar
  11. Doubal S, Klemera P (1999b) Methods of verification of aging theories. Ces Fyziologie 48(4):171–178Google Scholar
  12. Doubal S, Klemera P (2002) Visco-elastic response of human skin and aging. J Am Aging Assoc 3(25):115–117Google Scholar
  13. Doubal S, Klemera P, Filipová M, Dolejš J (1997) Teoretická gerontologie. Karolinum, PrahaGoogle Scholar
  14. Druga R (2008) Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat. Exp Gerontol 43:8Google Scholar
  15. Dufek M, Hamanová M, Lokaj, Goldemund D, Rektorová I, Michálková Z, Sheardová K, Rektor I (2009) Serum inflammatory biomarkers in Parkinson’s disease. Parkinsonism Rel Disord 15(4):318–320CrossRefGoogle Scholar
  16. Filip S, Mokrý J (2005) Stem cells, their plasticity, regeneration and ageing. Ces Ger Rev 3(4):51–56Google Scholar
  17. Hamerníková M, Koubská O, Zácková P, Doubal S (2008) Effect of the long-term application of melatonin on the state and vitality of rats. Folia Pharmaceutica, Universitatis Carolinae, p 37Google Scholar
  18. Hanus M, Matousková M, Starka L, Hill L (2006) Hormonal homeostasis in a group of 216 aging Czech males and correlation with responses to a questionnaire of the University of St Louis. Aging Male 9(2):103–110PubMedCrossRefGoogle Scholar
  19. Holmerová I (2010) History of Czech Gerontology. CGGS, PrahaGoogle Scholar
  20. Hort J, Laczo J, Vyhnalek M (2008) Spatial navigation deficit in amnestic Mild cognitive impairment. Proc Natl Acad Sci USA 104(10):4042–4047CrossRefGoogle Scholar
  21. Janderová-Rossmeislová L, Nováková Z, Vlasáková J, Philimonenko J, Hozák P, Hodný Z (2007) PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells. J Struct Biol 159(1):6–70CrossRefGoogle Scholar
  22. Juraskova B, Andrys I, Holmerova I, Solichova D, Hrnciarikova D, Vankova H, Vasatko T, Krejsek J (2009) Transforming growth factor beta and soluble endoglin in the healthy senior and in Alzheimer’s disease patients. J Nutr Health Aging. doi:10.1007/s12603-009-0146-2
  23. Kalová E, Vlcek K, Jarolímová E et al (2005) Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer’s disease: corresponding results in real space tests and computer tests. Behav Brain Res 159(2):175–186PubMedCrossRefGoogle Scholar
  24. Kalvach Z, Zadak Z, Jirak R (2004) Geriatrie a gerontologie [Geriatrics and gerontology] Prague. Grada Publishing, Czech RepublicGoogle Scholar
  25. Klemera P, Doubal S (2000) Gompertz—a program for evaluation and comparison of survival curves. AGE 23:129–130CrossRefGoogle Scholar
  26. Klemera P, Doubal S (2005) A new approach to the concept and computation of biological age. Mech Ageing Dev 127(3):240–248PubMedCrossRefGoogle Scholar
  27. Krejsek J, Kudlová M, Koláčková M (2005) Imunitní systém a stárnutí (The Immune System and Ageing). Ces Ger Rev 3(4):36–42Google Scholar
  28. Kristofiková Z, Benesová O, Tejkalová H (1993) Comparison of the effects of aging in vivo and of oxygen free radicals in vitro on high-affinity choline uptake and hemicholinium-3 binding in the rat brain. Arch Gerontol Geriatr 17(3):179–188PubMedCrossRefGoogle Scholar
  29. Kristofiková Z, Klaschka J, Tejkalová H (1995a) Effect of aging on lipid peroxide levels induced by L-glutamic acid and estimated by means of a thiobarbituric acid test in rat brain tissue. Exp Gerontol 30(6):645–657PubMedCrossRefGoogle Scholar
  30. Kristofiková Z, Fales E, Majer E, Klaschka J (1995b) 3H-hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer’s disease and multi-infarct dementia. Exp Gerontol 30(2):125–136PubMedCrossRefGoogle Scholar
  31. Kristofiková Z, Majer E, Fales E, Pĕkný I, Klaschka J (1998) Effects of aging and dementia on the levels of thiobarbituric-acid-reactive products stimulated by L-glutamic acid in human autopsy and biopsy brain tissue. Dement Geriatr Cogn Disord 9(1):6–12PubMedCrossRefGoogle Scholar
  32. Kristofiková Z, Bocková M, Hegnerová K, Bartos A, Klaschka J, Ricný J, Ripová D, Homola J (2009) Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. Mol Biosyst 5(10):1174–1179PubMedCrossRefGoogle Scholar
  33. Kubesová H, Holík J, Bogrová I, Syslová D (2001) Pain in elderly patients and aspects of its therapy. Cas Lek Ces 140(10):291–294Google Scholar
  34. Laczó J, Vlcek K, Vyhnálek M, Vajnerová O, Ort M, Holmerová I, Tolar M, Andel R, Bojar M, Hort J (2009) Spatial navigation testing discriminates two types of amnestic mild cognitive impairment. Behav Brain Res 202(2):252–259PubMedCrossRefGoogle Scholar
  35. Mazurova Y (2006) Apoptosis of subependymal cells as the reaction to the neurodegeneration in rat striatum. Univerzita Komenského v Bratislave: Morfológia v súčasnosti 222–227Google Scholar
  36. Motlík J, Hruska-Plochan M, Lacková M, Vodicka P, Usvald D, Pavlok A, Marsala M (2008) Miniature pig model of neurodegenerative diseases. In: Abstracts from 6th international symposium on experimental and clinical neurobiologyGoogle Scholar
  37. Ouda L, Druga R, Syka J (2008) Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat. Exp Gerontol 43(8):782–789PubMedCrossRefGoogle Scholar
  38. Pokorný J (2009) CNS its structure and function. Martin, OsvetaGoogle Scholar
  39. Procházková D, Wilhelmová N (2007) Leaf senescence and activities of the antioxidant enzymes. Biologia Plantarum 51(3):41–46CrossRefGoogle Scholar
  40. Rektorova I (2008) Demence u Parkinsonovy nemoci (Dementia in Parkinsons′s Disease). Ceská Geriatrická Revue 6(4):171–176Google Scholar
  41. Rofina JE, Singh K, Skoumalová-Veselá A, van Ederen AM, van Asten AJAM, Wilhelm J, Gruys E (2004) Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine. Amyloid 11:90–100PubMedCrossRefGoogle Scholar
  42. Rokyta R (2004) Patofyziologie bolesti ve vyšším věku a ve stáří (Patophysiology of pain in older and old age). Ces Ger Rev 2(1):22–26Google Scholar
  43. Rokyta R (2005) Volně radikálová teorie stárnutí (Ageing and the free radicals theory). Ces Ger Rev 3(1):27–33Google Scholar
  44. Rusina R, Ridzoň P, Kulišt’ák P, Keller O, Bartoš A, Buncová M et al (2010) Relationship between ALS and the degree of cognitive impairment, markers of neurodegeneration and predictors for poor outcome. A prospective study. Eur J Neurol 17:23–30PubMedCrossRefGoogle Scholar
  45. Sajko S, Kubínová L, Kreft M, Dahmane R, Wernink A, Erzen I (2002) Improving methodological strategies for satellite cells counting in human muscle during ageing. Image Anal Stereol 21(1):7–12Google Scholar
  46. Skoumalová A, Rofina J, Schwippelová Z, Gruys E, Wilhelm J (2003) The role of free radicals in canine counterpart of senile dementia of the Alzheimer type. Exp Gerontol 38:711–719PubMedCrossRefGoogle Scholar
  47. Skrha J (2009) Effect of caloric restriction on oxidative markers. Adv Clin Chem 47:224–242Google Scholar
  48. Srbová M, Wilhelmová N, Wilhelm J (2001) Molekulární mechanismy stárnutí živočichů a rostlin vycházejících z oxidačního stresu (Molecular mechanisms of ageing based on the oxidative stress both of animals and plants). Biologické listy 66(3):203–220Google Scholar
  49. Stárka L (2003) Stárnoucí muž z pohledu endokrinologa (Ageing male from the point of view of endocrinologist). Ces Ger Rev 1(3):6–12Google Scholar
  50. Strunecká A (2004) Synergistic effects of aluminium and fluoride on the pathophysiological hallmarks of Alzheimer′s dementia. Physiol Res 53(4):34–35Google Scholar
  51. Topinková E (2008) Aging, disability and frailty. Ann Nutr Metab 52(Suppl 1):6–11PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Iva Holmerová
    • 1
  • Hana Vanková
    • 1
  • Bozena Jurasková
    • 2
  1. 1.Centre of GerontologyPraha 8Czech Republic
  2. 2.Teaching Hospital Hradec Králové, Faculty of Medicine in Hradec KraloveCharles UniversityHradec KrálovéCzech Republic

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