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Biogerontology

, Volume 11, Issue 4, pp 463–473 | Cite as

Interaction networks as a tool to investigate the mechanisms of aging

  • Emilie Chautard
  • Nicolas Thierry-Mieg
  • Sylvie Ricard-Blum
Research Article

Abstract

Biological systems are made up of very large numbers of different components interacting at various scales. Most genes, proteins and other cell components carry out their functions within a complex network of interactions and a single component can affect a wide range of other components. Interactions involved in biological processes have been first characterized individually but this “reductionist” approach suffers from a lack of information about time, space, and context in which the interactions occur in vivo. A global, integrative, approach has been developed for several years, focusing on the building of protein–protein interaction maps or interactomes. These interaction networks are complex systems, where new properties arise. They are part of the emergent field of systems biology, which focuses on studying complex biological systems such as a cell or organism, viewed as an integrated and interacting network of genes, proteins and biochemical reactions. Aging is associated with many diseases, such as cancer, diabetes, cardiovascular and neurodegenerative disorders and this limits the investigation of the mechanisms underlying the aging process when focusing on a single gene or a single biochemical pathway. The integration of existing intracellular interaction networks with the extracellular interaction network we have developed (MatrixDB, http://matrixdb.ibcp.fr) will contribute to provide further insights into the global mechanisms of aging.

Keywords

Interaction networks Aging Extracellular matrix 

Abbreviation

GO

Gene Ontology

Notes

Acknowledgments

This work was supported by a grant from Region Rhône-Alpes (CPER to EC, NTM, and SRB), and by the “Institut Rhône-Alpin des Systèmes Complexes” (IXXI 2007, to EC, NTM, and SRB).

Supplementary material

10522_2010_9268_MOESM1_ESM.pdf (5.7 mb)
Supplementary material 1 (PDF 5831 kb)

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Emilie Chautard
    • 1
  • Nicolas Thierry-Mieg
    • 2
  • Sylvie Ricard-Blum
    • 1
  1. 1.Institut de Biologie et Chimie des ProtéinesUMR 5086 CNRS, Université Lyon 1Lyon Cedex 07France
  2. 2.Faculté de MédecineTIMC-IMAG, UMR 5525 CNRS, Université Grenoble 1La Tronche CedexFrance

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