, Volume 10, Issue 4, pp 489–502 | Cite as

Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions

  • Deepak Sharma
  • Pallavi Sethi
  • Ezaj Hussain
  • Rameshwar Singh
Research Article


This study investigated the effect of curcumin on aluminium-induced alterations in ageing-related parameters: lipid peroxidation, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST), protein kinase C (PKC), Na+, K+-adenosine triphosphatase (Na+, K+-ATPase) and acetylcholinesterase (AChE) in the cerebral cortex and hippocampus of the brain of 10- and 24-month-old rats. Measurements taken from aluminium-fed rats were compared with those from rats in which curcumin and aluminium were co-administered. In aluminium-treated rats the levels of lipid peroxidation, PKC and AChE were enhanced while the activities of SOD, GPx, GST and Na+, K+-ATPase were significantly decreased in both the brain regions of both age-groups. In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na+, K+-ATPase were significantly enhanced in the two brain regions studied indicating curcumin’s protective effects against aluminium toxicity. Though the magnitudes of curcumin-induced alterations varied in young and old animals, the results of the present study also demonstrated that curcumin exerts a protective effect against aluminium-induced elevation of ageing-related changes by modulating the extent of oxidative stress (by upregulating the activities of antioxidant enzymes) and by regulating the activities of Na+, K+ ATPase, PKC and AChE. Therefore, it is suggested that curcumin counters aluminium-induced enhancement in ageing-related processes.


Anti-ageing effects Antioxidant enzymes Curcumin Na+ K+-ATPase Protein kinase C Aluminium-induced neurotoxicity Glutathione-s-transferase Superoxide dismutase Glutathione peroxidase Lipid peroxidation Oxidative stress 


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Deepak Sharma
    • 1
  • Pallavi Sethi
    • 1
  • Ezaj Hussain
    • 2
  • Rameshwar Singh
    • 1
  1. 1.School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.School of BiosciencesJamia Millia Islamia UniversityNew DelhiIndia

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