Biogerontology

, Volume 10, Issue 2, pp 97–108

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

  • Eugenio Barone
  • Vittorio Calabrese
  • Cesare Mancuso
Review Article

DOI: 10.1007/s10522-008-9160-8

Cite this article as:
Barone, E., Calabrese, V. & Mancuso, C. Biogerontology (2009) 10: 97. doi:10.1007/s10522-008-9160-8

Abstract

Ferulic acid (FA) is a polyphenol very abundant in vegetables and maize bran. Several lines of evidence have shown that FA acts as a potent antioxidant in vitro, due to its ability to scavenge free radicals and induce a robust cell stress response through the up-regulation of cytoprotective enzymes such as heme oxygenase-1, heat shock protein 70, extracellular signal-regulated kinase 1/2 and Akt. Furthermore, FA inhibited the expression and/or activity of cytotoxic enzymes including inducible nitric oxide synthase, caspases and cyclooxygenase-2. On this basis, FA has been proposed for the treatment of several age-related diseases such as neurodegenerative disorders, cardiovascular diseases, diabetes and cancer. However, although the great abundance of in vitro data, the real efficacy of FA in humans has not been demonstrated so far. New efforts and resources should be transferred to clinical research for the complete evaluation of the therapeutic potential of FA in chronic diseases.

Keywords

Aging Ferulic acid Free radicals Heme oxygenase Neurodegenerative disorders 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Eugenio Barone
    • 1
  • Vittorio Calabrese
    • 2
  • Cesare Mancuso
    • 1
  1. 1.Institute of PharmacologyCatholic University School of MedicineRomeItaly
  2. 2.Department of ChemistryUniversity of CataniaCataniaItaly

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