Biogerontology

, 7:221 | Cite as

Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments

  • Anders Olsen
  • Maithili C. Vantipalli
  • Gordon J. Lithgow
RESEARCH ARTICLE

Abstract

Mild hormetic heat treatments early in life can significantly increase the lifespan of the nematode C. elegans. We have examined the effects of heat treatments at different ages and show that treatments early in life cause the largest increases in lifespan. We also find that repeated mild heat treatments throughout life have a larger effect on lifespan compared to a single mild heat treatment early in life. We hypothesize that the magnitude of the hormetic effect is related to the levels of heat shock protein expression. Following heat treatment young worms show a dramatic increase in the levels of the small heat shock protein HSP-16 whereas old worms are a 100-fold less responsive. The levels of the heat shock proteins HSP-4 and HSP-16 correlate well with the effects on lifespan by the hormetic treatments.

Keywords

Ageing Aging C. elegans Chaperones Hormesis Lifespan Stress 

Abbreviations

UPR

unfolded protein response

ER

endoplasmic reticulum

HSP

heat shock protein

GFP

green fluorescent protein

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Anders Olsen
    • 1
  • Maithili C. Vantipalli
    • 1
  • Gordon J. Lithgow
    • 1
  1. 1.The Buck InstituteNovatoUSA

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