Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans
- 373 Downloads
Calorie restriction is known to increase lifespan in many but not all species and may perhaps not do so in humans. Exceptions to life extension have been identified in the laboratory and others are known in nature. Given the variety of physiological responses to variation in food supply that are possible, evolutionary life history theory indicates that an increased investment in maintenance in response to resource shortage will not always be the strategy that maximises Darwinian fitness. Additionally, for the well-studied species in which life extension is observed, there is considerable variation in the response. This suggests that it is not an ancient ancestral response, which has been conserved across the species range. Although calorie restriction does not increase lifespan in all species, it remains a fascinating and valuable tool to study ageing at the whole organism level.
KeywordsCalorie restriction Comparative studies Disposable soma theory Life history Phenotypic plasticity
Unable to display preview. Download preview PDF.
- Buffenstein R (2005) The naked mole-rat? A new long-living model for human aging research. J Geront Ser A 60:1369–1377Google Scholar
- Keys A, Brozek J, Henschel A, Mickelsen O, Taylor HL (1950) The biology of human starvation. University of Minnesota Press, Minneapolis, MNGoogle Scholar
- Kirk KL (2001) Dietary restriction and aging: comparative tests of evolutionary hypotheses. J Geront Ser A 56:B123–B129Google Scholar
- Lane MA, Mattison JA, Roth GS, Brant LJ, Ingram DK (2004) Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Geront Ser A 59:405–407Google Scholar
- LeBourg E, Minois N (1996) Failure to confirm increased longevity in Drosophila melanogaster submitted to a food restriction procedure. J Geront Ser A 51:B280–B283Google Scholar
- Masoro EJ, Austad SN (1996) The evolution of the anti-aging action of dietary restriction: a hypothesis. J Geront Ser A 51:B387–B391Google Scholar
- Pinney DO, Stephens DF, Pope LS (1972) Lifetime effects of Winter supplemental feed level and age at first parturition on range beef cows. J Anim Sci 34:1067–1074Google Scholar
- Prentice AM, Whitehead RG (1987) The energetics of human reproduction. Symp Zool Soc 57:275–304Google Scholar
- Walford RL, Mock D, Verdery R, MacCallum T (2002) Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J Geront Ser A 57:B211–B224Google Scholar