, Volume 7, Issue 2, pp 81–89 | Cite as

Neuroprotective and Anti-ageing Effects of Curcumin in Aged Rat Brain Regions

  • Kiran Bala
  • B. C. Tripathy
  • Deepak Sharma
Research Article


This study investigated the influence of chronically administered curcumin on normal ageing-related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na+, K+, -adenosine triphosphatase (Na+, K+, -ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6- and 24-month-old rats. In normal ageing, lipid peroxidation and lipofuscin concentration were found to increase with ageing, the activities of SOD, GPx and Na+, K+, -ATPase, however, decreased with ageing. Chronic curcumin treatment of both 6 and 24 months old rats resulted in significant decreases in lipid peroxide and the lipofuscin contents in brain regions, the activities of SOD, GPx and Na+, K+, -ATPase however, showed significant increase in various brain regions. The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain.


anti-ageing effects antioxidant enzymes curcumin lipofuscin Na + K+-ATPase 


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Copyright information

© Springer 2006

Authors and Affiliations

  1. 1.School of Life Sciences, Jawaharlal Nehru UniversityNew DelhiIndia

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