Biogerontology

, Volume 6, Issue 4, pp 255–260

A Cross-sectional Study of Homocysteine-, NO-levels, and CT-findings in Alzheimer Dementia, Vascular Dementia and Controls

  • Marcella Folin
  • Silvia Baiguera
  • Maurizio Gallucci
  • Maria Teresa Conconi
  • Rosa Di Liddo
  • Andrea Zanardo
  • Pier Paolo Parnigotto
Research Article

Abstract

Repetitive measurement with neuroimaging techniques could be useful instruments permitting to differentiate between Alzheimer disease (AD) and vascular dementia (VD). The major genetic risk factor for the development of late-onset AD is the allele ε4 of the apolipoprotein E (ApoE). Moreover nitric oxide (NO) and homocysteine (Hcy) seems to be correlated with the degree of cognitive impairment in demented subjects. The aim of this study was to investigate the association between serum NO and Hcy levels, global brain atrophy and brain vascular lesion in AD and VD patients. We report that high plasma levels of homocysteine resulted associated with AD and VD, suggesting that in AD elevated plasma Hcy might be a consequence of concomitant vascular dementia. Otherwise, plasma NO levels were not significantly different in any of the groups. Moreover, neuroimaging measures of vascular lesion level could be of usefulness to differentiate between AD and VD.

Keywords

Alzheimer’s disease apolipoprotein E cognitive impairment homocysteine neuroimaging nitric oxide vascular dementia 

Abbrevaitions

AD

Alzheimer disease

ApoE

apolipoprotein E

CAT

computer axial tomography

CDRS

clinical demetia rating scale

Hcy

homocysteine

MMSE

mini mental state examination

MR

magnetic resonance

NINCDS-ADRDA

National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association

NINDS-AIREN

National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l’Enseignement en Neurosciences

NO

nitric oxide

VD

vascular dementia

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Copyright information

© Springer 2005

Authors and Affiliations

  • Marcella Folin
    • 1
  • Silvia Baiguera
    • 1
  • Maurizio Gallucci
    • 3
  • Maria Teresa Conconi
    • 2
  • Rosa Di Liddo
    • 2
  • Andrea Zanardo
    • 4
  • Pier Paolo Parnigotto
    • 2
  1. 1.Departments of BiologyUniversity of PaduaPaduaItaly
  2. 2.Pharmaceutical SciencesUniversity of PaduaPaduaItaly
  3. 3.Ca’ Foncello HospitalTrevisoItaly
  4. 4.Clinical Chemistry Laboratory, Ca’ Foncello HospitalTrevisoItaly

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