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Biogerontology

, Volume 5, Issue 6, pp 411–419 | Cite as

Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups

  • K. Moorthy
  • Umesh C. S. Yadav
  • Anil K Mantha
  • Sudha M. Cowsik
  • D. Sharma
  • S. F. Basir
  • N. Z. Baquer
Research Article

Abstract

The effect of estradiol and progesterone therapy in serum and liver on the lipid profile of naturally menopausal albino rats of the Wistar strain of different age groups (12,18 and 24months) have been measured and compared with the age matched groups. Three months old rats were used as young controls. The aged rats were administered subcutaneous injection of 17-β-estradiol (0.1 μg/g body weight), progesterone (2.5 μg/g body weight) and similar concentrations of both in combined treatment for 1month and the level of triglycerides (TG), total lipids (TL), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were measured in serum and liver of 3, 12, 18 and 24months old control as well as treated groups. The results show that TG, HDL, VLDL levels were increased significantly by 71%, 155%, 54%, respectively in liver of 24months old rats by combination treatment when compared with age matched control animals. The levels of TL, TC and LDL were decreased by 20%, 31%, and 30%, respectively in serum of 12 months old rats in combination treatment group. The effect was more significant in 12 and 24 months old female rats with administration of estrogen and combined (EP) treatments. The results indirectly suggest that hormone replacement therapy (HRT) can reduce the risk of cardiovascular disease (CVD) thereby playing a cardio-protective role by restoring lipid and hormone levels to the similar levels as found in young female animals.

Keywords

aging estradiol and progesterone hormone replacement therapy (HRT) lipid 

Abbreviations

CVD

cardiovascular disease

E2

estradiol

EP

combination of estradiol and progesterone

HDL

high density lipoprotein

HRT

hormone replacement therapy

LDL

low density lipoprotein

P4

progesterone

TC

total cholesterol

TG

triglyceride

TL

total lipid

VLDL

very low density lipoprotein

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • K. Moorthy
    • 1
  • Umesh C. S. Yadav
    • 1
  • Anil K Mantha
    • 1
  • Sudha M. Cowsik
    • 1
  • D. Sharma
    • 1
  • S. F. Basir
    • 2
  • N. Z. Baquer
    • 1
  1. 1.Hormone and Drug Research Laboratory, School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Department of BiosciencesJamia Millia IslamiaNew DelhiIndia

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