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Behavior Genetics

, Volume 46, Issue 3, pp 353–364 | Cite as

Maternal Smoking During Pregnancy and Offspring Birth Weight: A Genetically-Informed Approach Comparing Multiple Raters

  • Valerie S. Knopik
  • Kristine Marceau
  • Rohan H. C. Palmer
  • Taylor F. Smith
  • Andrew C. Heath
Original Research

Abstract

Maternal smoking during pregnancy (SDP) is a significant public health concern with adverse consequences to the health and well-being of the fetus. There is considerable debate about the best method of assessing SDP, including birth/medical records, timeline follow-back approaches, multiple reporters, and biological verification (e.g., cotinine). This is particularly salient for genetically-informed approaches where it is not always possible or practical to do a prospective study starting during the prenatal period when concurrent biological specimen samples can be collected with ease. In a sample of families (N = 173) specifically selected for sibling pairs discordant for prenatal smoking exposure, we: (1) compare rates of agreement across different types of report—maternal report of SDP, paternal report of maternal SDP, and SDP contained on birth records from the Department of Vital Statistics; (2) examine whether SDP is predictive of birth weight outcomes using our best SDP report as identified via step (1); and (3) use a sibling-comparison approach that controls for genetic and familial influences that siblings share in order to assess the effects of SDP on birth weight. Results show high agreement between reporters and support the utility of retrospective report of SDP. Further, we replicate a causal association between SDP and birth weight, wherein SDP results in reduced birth weight even when accounting for genetic and familial confounding factors via a sibling comparison approach.

Keywords

Birth weight Genetics Sibling comparison design Multiple reporters Smoking during pregnancy 

Notes

Funding

This work supported by NIH Grants: DA023134 (Knopik), DA17671 (Knopik), AA07728 (Heath), AA09022 (Heath), AA11998 (Heath), HD049024 (Heath), AA017688 (Heath), AA021492 (Heath). Dr. Marceau is supported by T32 DA016184. Dr. Palmer is supported by K01 AA021113 and L30 TR001045. Dr. Smith is supported by T32 MH19927.

Compliance with ethical standards

Conflicts of interest

Valerie S. Knopik, Kristine Marceau, Rohan H.C. Palmer, Taylor F. Smith, and Andrew C. Heath declare that they have no conflicts of interest.

Human and animal rights and informed consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Division of Behavioral Genetics, Department of PsychiatryRhode Island HospitalProvidenceUSA
  2. 2.Department of Psychiatry and Human BehaviorBrown UniversityProvidenceUSA
  3. 3.Center for Alcohol and Addiction StudiesBrown UniversityProvidenceUSA
  4. 4.Department of Psychology and Child DevelopmentCalifornia Polytechnic State UniversitySan Luis ObispoUSA
  5. 5.Midwest Alcoholism Research Center, Department of PsychiatryWashington University School of MedicineSt LouisUSA

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