Behavior Genetics

, Volume 46, Issue 1, pp 100–113

Widowhood and the Stability of Late Life Depressive Symptomatology in the Swedish Adoption Twin Study of Aging

  • Christopher R. Beam
  • Robert E. Emery
  • Chandra A. Reynolds
  • Margaret Gatz
  • Eric Turkheimer
  • Nancy L. Pedersen
Original Research

DOI: 10.1007/s10519-015-9733-7

Cite this article as:
Beam, C.R., Emery, R.E., Reynolds, C.A. et al. Behav Genet (2016) 46: 100. doi:10.1007/s10519-015-9733-7

Abstract

Although the Swedish Adoption Twin of Aging (SATSA) has been used to investigate phenotypic stability of late life depressive symptoms, the biometric processes underlying this stability have not been studied. Under a reciprocal effects modeling framework, we used SATSA twins’ Center for Epidemiologic Studies Depression (CES-D) Scale data across 5 waves (from 1987–2007) to test whether the reciprocal exchange between twins within a family and their nonshared environments (P<=>E) promote the accumulation of gene-environment correlation (rGE) over time. The model generates increasing rGE that produces subsequent stable environmental differences between twins within a family—a process hypothesized to explain stability in chronic late life depressive symptoms. Widowhood is included as a stressful life experience that may introduce an additional nonshared source of variability in CES-D scores. Genetic effects and nonshared environmental effects are primary sources of stability of late life depressive symptoms without evidence of underlying rGE processes. Additionally, widowhood explained stable differences in CES-D scores between twins within a family up to 3 years after spousal loss.

Keywords

Depressive symptomatology Late life depression Reciprocal effects model Gene-environment correlation Nonshared environment 

Supplementary material

10519_2015_9733_MOESM1_ESM.docx (244 kb)
Supplementary material 1 (DOCX 244 kb)

Funding information

Funder NameGrant NumberFunding Note
National Institute on Aging
  • 1F31AG044047-01A1
  • T32AG020500
National Institute of Child Health and Human Development
  • 1R01HD056354-01

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.University of VirginiaCharlottesvilleUSA
  2. 2.University of CaliforniaRiversideUSA
  3. 3.Department of PsychologyUniversity of Southern CaliforniaLos AngelesUSA
  4. 4.Karolinska InstituteStockholmSweden

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