Cadherin-7 (CDH7) gene encodes a calcium dependent cell–cell adhesion glycoprotein. Gene loci of cadherins family have been supposed to be involved in the pathogenesis of psychiatric disorders. Recent genome-wide association study also demonstrated that CDH7 was significant associated with bipolar disorder. Due to the fact that the same genetic risk factor can be shared by different kinds of psychiatric disorders, we examined whether CDH7 is also associated with major depressive disorder (MDD) in this study, with a large Han Chinese sample set. We carried out a 2-stage case–control study to examine the association between CDH7 and MDD in the Han Chinese population. Ten tag SNPs were genotyped using Taqman technology in 1,045 MDD patients and 1,520 healthy controls. Single-nucleotide polymorphisms with significance were additionally genotyped in another independent sample set with 576 MDD cases and 576 healthy controls. Among ten genotyped SNPs, rs1444067 and rs12605720 was found to be significantly associated with MDD (rs1444067: Pallele = 0.00571, OR 0.830, 95 % CI 0.728–0.947; rs12605720: Pallele = 0.00321, OR 1.245, 95 % CI 1.076–1.441). We successfully replicated these two SNPs association with independent sample sets (rs1444067: Pallele = 0.00518; rs12605720: Pallele = 0.0227). Finally we have combined these results by a meta-analysis (rs1444067: Pallele = 0.000174, OR 0.817; rs12605720: Pallele = 0.000199, OR 1.255). Our results support CDH7 to be a risk factor of MDD in the Han Chinese population. However, further studies with more markers and independent samples were suggested to validate our findings.
CDH7 Major depressive disorder Case–control study
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We warmly thanks all patients and healthy individuals who participated in our study. This work was supported by the Natural Science Foundation of China (81130022, 81272302, 31000553, 81121001, 31240001, 31271140), the National 863 project (2012AA02A515), the 973 Program (2010CB529600), Program for Changjiang Scholars and Innovative Research Team in University (IRT1025), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), the Program for New Century Excellent Talents in University (NCET-09-0550), Shanghai Science and Technology Development Funds (12QA1401900).
Conflict of Interest
Xingwang Li, Qingzhong Wang, Kuanjun He, Zhiqiang Li, Jianhua Chen, Wenjin Li, Zujia Wen, Jiawei Shen, Yu Qiang, Jue Ji, Guoyin Feng, Guang He, He Lin, Yonggang Wang, and Yongyong Shi declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for being included in the study.
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