Behavior Genetics

, Volume 43, Issue 1, pp 24–33 | Cite as

Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders

  • Margarita C. T. Slof-Op’t Landt
  • Meike Bartels
  • Christel M. Middeldorp
  • Catherina E. M. van Beijsterveldt
  • P. Eline Slagboom
  • Dorret I. Boomsma
  • Eric F. van Furth
  • Ingrid Meulenbelt
Original Research


Genes are involved in eating disorders (EDs) and self-induced vomiting (SV), a key symptom of different types of EDs. Perfectionism and impulsivity are potential risk factors for EDs. TPH2 (tryptophan hydroxylase 2) SNP rs1473473 was previously associated with anorexia nervosa and EDs characterized by SV. Could perfectionism or impulsivity be underlying the association between rs1473473 and EDs? Genetic association between TPH2 SNP rs1473473 and perfectionism or impulsivity was first evaluated in a random control group (N = 512). The associations obtained in this control group were subsequently tested in a group of patients with an ED (N = 267). The minor allele of rs1473473 (OR = 1.49) was more frequent in impulsive controls, but also in impulsive patients with an ED (OR = 1.83). The largest effect was found in the patients with an ED characterized by SV (OR = 2.51, p = 0.02). Genetic variation at the TPH2 gene appeared to affect impulsivity which, in turn, might predispose to the SV phenotype.


Eating disorders Perfectionism Impulsivity TPH2 Association analysis 



We would like to thank the patients and control women for their participation in this study. Participating centers in the Netherlands were Amarum, Emergis, Psychotherapy Practice H. van Agteren, Mentrum, Mesos, PsyQ, GGZ Oost-Brabant, Breburggroep, GGZ Eindhoven. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007–2011) under grant agreement no. 259679. The study was supported by the Netherlands Organization for Scientific Research NWO/ZonMW (NWO 985-10-002, NWO/SPI 56-464- 14192, NWO 480-04-004, ‘Genetic and Family influences on Adolescent Psychopathology and Wellness’ NWO 463-06-001, ZonMW 911-03-016, ZonMW 91210020) and the ‘Bridge Award’ (NIMH R56). M. Bartels was financially supported by a senior fellowship of the EMGO + institution and by NWO (VENI 451-04-034). C. M. Middeldorp was financially supported by NWO-ZonMw (VENI grant 916-76-125).

Supplementary material

10519_2012_9569_MOESM1_ESM.doc (40 kb)
Supplementary material 1 (DOC 39 kb)


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Margarita C. T. Slof-Op’t Landt
    • 1
    • 2
    • 3
  • Meike Bartels
    • 3
  • Christel M. Middeldorp
    • 3
    • 4
    • 5
  • Catherina E. M. van Beijsterveldt
    • 3
  • P. Eline Slagboom
    • 2
    • 6
  • Dorret I. Boomsma
    • 3
  • Eric F. van Furth
    • 1
  • Ingrid Meulenbelt
    • 2
  1. 1.Center for Eating Disorders UrsulaLeidschendamThe Netherlands
  2. 2.Department of Medical Statistics, Molecular Epidemiology SectionLeiden University Medical CentreLeidenThe Netherlands
  3. 3.Department of Biological PsychologyVU UniversityAmsterdamThe Netherlands
  4. 4.Department of Child and Adolescent PsychiatryAcademic Medical Center AmsterdamAmsterdamThe Netherlands
  5. 5.Department of Child and Adolescent Psychiatry, GGZ inGeestVU Medical CenterAmsterdamThe Netherlands
  6. 6.Netherlands Consortium for Healthy AgeingLeiden University Medical CenterLeidenThe Netherlands

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