Behavior Genetics

, Volume 42, Issue 3, pp 402–414

Externalizing Behaviors are Associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster

  • Sarah H. Stephens
  • Nicole R. Hoft
  • Isabel R. Schlaepfer
  • Susan E. Young
  • Robin C. Corley
  • Matthew B. McQueen
  • Christian Hopfer
  • Thomas Crowley
  • Michael Stallings
  • John Hewitt
  • Marissa A. Ehringer
Original Research

Abstract

There is strong evidence for shared genetic factors contributing to childhood externalizing disorders and substance abuse. Externalizing disorders often precede early substance experimentation, leading to the idea that individuals inherit a genetic vulnerability to generalized disinhibitory psychopathology. Genetic variation in the CHRNA5/CHRNA3/CHRNB4 gene cluster has been associated with early substance experimentation, nicotine dependence, and other drug behaviors. This study examines whether the CHRNA5/CHRNA3/CHRNB4 locus is correlated also with externalizing behaviors in three independent longitudinally assessed adolescent samples. We developed a common externalizing behavior phenotype from the available measures in the three samples, and tested for association with 10 SNPs in the gene cluster. Significant results were detected in two of the samples, including rs8040868, which remained significant after controlling for smoking quantity. These results expand on previous work focused mainly on drug behaviors, and support the hypothesis that variation in the CHRNA5/CHRNA3/CHRNB4 locus is associated with early externalizing behaviors.

Keywords

Nicotinic receptor genes Externalizing behaviors Association study Disinhibition Drug behaviors 

Supplementary material

10519_2011_9514_MOESM1_ESM.ppt (156 kb)
Supplementary material 1 (PPT 156 kb)
10519_2011_9514_MOESM2_ESM.docx (17 kb)
Supplementary material 2 (DOCX 17 kb)

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sarah H. Stephens
    • 1
    • 3
  • Nicole R. Hoft
    • 3
  • Isabel R. Schlaepfer
    • 4
  • Susan E. Young
    • 3
  • Robin C. Corley
    • 3
  • Matthew B. McQueen
    • 1
    • 3
  • Christian Hopfer
    • 5
  • Thomas Crowley
    • 5
  • Michael Stallings
    • 2
    • 3
  • John Hewitt
    • 2
    • 3
  • Marissa A. Ehringer
    • 1
    • 3
  1. 1.Department of Integrative PhysiologyUniversity of Colorado BoulderBoulderUSA
  2. 2.Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderUSA
  3. 3.Institute for Behavioral GeneticsUniversity of Colorado BoulderBoulderUSA
  4. 4.Division of Endocrinology, Metabolism, and DiabetesUniversity of Colorado DenverDenverUSA
  5. 5.Department of PsychiatryUniversity of Colorado DenverDenverUSA

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