Behavior Genetics

, Volume 41, Issue 4, pp 499–511 | Cite as

Heritability and Longitudinal Stability of Schizotypal Traits During Adolescence

  • Marissa Ericson
  • Catherine Tuvblad
  • Adrian Raine
  • Kelly Young-Wolff
  • Laura A. Baker
Original Research

Abstract

The study investigated the genetic and environmental etiology of schizotypal personality traits in a non-selected sample of adolescent twins, measured on two occasions between the ages of 11 and 16 years old. The 22-item Schizotypal Personality Questionnaire- Child version (SPQ-C) was found to be factorially similar to the adult version of this instrument, with three underlying factors (Cognitive-Perceptual, Interpersonal-Affective, and Disorganization). Each factor was heritable at age 11–13 years (h2 = 42–53%) and 14–16 years old (h2 = 38–57%). Additive genetic and unique environmental influences for these three dimensions of schizotypal personality acted in part through a single common latent factor, with additional genetic effects specific to both Interpersonal-Affective and Disorganization subscales at each occasion. The longitudinal correlation between the latent schizotypy factor was r = 0.58, and genetic influences explained most of the stability in this latent factor over time (81%). These longitudinal data demonstrate significant genetic variance in schizotypal traits, with moderate stability between early to middle adolescence. In addition to common influences between the two assessments, there were new genetic and non-shared environmental effects that played a role at the later assessment, indicating significant change in schizotypal traits and their etiologies throughout adolescence.

Keywords

Schizotypy Schizotypal personality Genetics Heritability Longitudinal 

Notes

Acknowledgments

This study was funded by NIMH (R01 Laura A. Baker). Catherine Tuvblad was supported by post-doctoral stipends from the Swedish Council for Working Life and Social Research (Project 2006-1501) and the Sweden-America Foundation. Adrian Raine was supported by NIMH (Independent Scientist Award K02 MH01114-08). We thank the Southern California Twin Project staff for their assistance in collecting data, and the twins and their families for their participation. We also appreciate the help of Erin Skrok in developing child-appropriate wording for the SPQ-C items.

References

  1. Akaike H (1987) Factor analysis and AIC. Psychometrika 52:42–48CrossRefGoogle Scholar
  2. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (4th ed.) Author, Washington, DCGoogle Scholar
  3. Axelrod SR, Grilo MC, Sanislow C, McGlashan TH (2001) Schizotypal Personality Questionnaire—Brief: factor structure and convergent validity in inpatient adolescent. J. Personal. Disord. 15:168–179CrossRefGoogle Scholar
  4. Baker LA, Barton M, Lozano DI, Raine A, Fowler JH (2006) The Southern California Twin Register at the University of Southern California: II. Twin Res Human Genetics 9(6):933–940CrossRefGoogle Scholar
  5. Baker LA, Jacobson KC, Raine A, Lozano DI, Bezdjian S (2007) Genetic and environmental bases of childhood antisocial behavior: a multi-informant twin study. J Abnorm Psychol 116(2):219–235PubMedCrossRefGoogle Scholar
  6. Bedwell JS, Donnelly RS (2005) Schizotypal personality disorder or prodromal symptoms of schizophrenia? Schizophr Res 80:263–269PubMedCrossRefGoogle Scholar
  7. Chang C-J, Chen WJ, Liu S-K, Cheng JJ, Ou Yang W-C, Chang H-J (2002) Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in Taiwan. Schizophr Bull 28:379–392PubMedGoogle Scholar
  8. Chapman LJ, Chapman JP, Raulin ML (1978) Body-image aberration in schizophrenia. J Abnorm Psychol 87:399–407PubMedCrossRefGoogle Scholar
  9. Chapman LJ, Chapman JP, Kwapil TR, Eckblad M, Zinser MC (1994) Putatively psychosis-prone subjects 10 years later. J Abnorm Psychol 103:171–183PubMedCrossRefGoogle Scholar
  10. Chen WJ, Hsiao CK, Lin CCH (1997) Schizotypy in community samples: the three-factor structure and correlation with sustained attention. J Abnorm Psychol 106:649–654PubMedCrossRefGoogle Scholar
  11. Chen WJ, Liu SK, Chang CJ, Lien YJ, Chang YH, Hwu HG (1998) Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. American Journal of Psychiatry 155:1214–1220PubMedGoogle Scholar
  12. Claridge GS (1987) ‘The schizophrenias as nervous types’ revisited. Br J Psychiatry 151:735–743PubMedCrossRefGoogle Scholar
  13. Claridge G (1997) Theoretical background and issues. In: Claridge G (ed) Schizotypy. Implications for illness and health. Oxford University Press, New YorkGoogle Scholar
  14. Claridge GS, Broks P (1984) Schziotypy and hemisphere function-I. Theoretical consideration and the measurement of schizotypy. Personal Individ Differ 5:633–648CrossRefGoogle Scholar
  15. Claridge G, Hewitt J (1987) A biometrical study of schizotypy in a normal population. Personal Individ Differ 8:303–312CrossRefGoogle Scholar
  16. Claridge G, McCreery C, Mason O, Bentall R, Boyle G, Slade P, Popplewell D (1996) The factor structure of ‘schizotypal’ traits: a large replication study. Br J Clin Psychol 35:103–115PubMedGoogle Scholar
  17. Ericson M, Tuvblad C, Lozano DI, Raine A, Baker LA (2008) Genetic and environmental overlap among schizophrenia spectrum endophenotypes and schizotypal traits during childhood and adolescence (conference presentation). Behav Genet 38:625Google Scholar
  18. Erlenmeyer-Kimling L (2001) Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis. American Journal of Medical Genetics 105:23–34PubMedCrossRefGoogle Scholar
  19. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Arch Gen Psychiatry 160(4):636–645Google Scholar
  20. Gruzelier J, Burgess A, Stygall J, Irving G, Raine A (1995) Patterns of cognitive asymmetry and syndromes of schizotypal personality. Psychiatry Research 56:71–79PubMedCrossRefGoogle Scholar
  21. Gruzelier, Kaiser J (1996) Syndromes of schizotypy and timing of puberty. Schizophr Res 21(3):183–194PubMedCrossRefGoogle Scholar
  22. Hall MH, Rijsdijk F, Kalidindi S, Schulze K, Kravariti E, Kane F, Sham P, Bramon E, Murray RM (2007) Genetic overlap between bipolar illness and event-related potentials. Psychological Medicine 37:667–678PubMedCrossRefGoogle Scholar
  23. Kendler KS (1985) Diagnostic approaches to schizotypal personality disorder: a historical perspective. Schizophrenia Bull 11(4), 538–555Google Scholar
  24. Kendler KS, Gruenberg AM, Strauss JS (1981) An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia, II: the relationship between schizotypal personality disorder and schizophrenia. Arch Gen Psychiatry. 38(9):982–998PubMedGoogle Scholar
  25. Kendler KS, McGuire M, Gruenberg AM, O’Hare A, Spellman M, Walsh D (1993) The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Archives of General Psychiatry 50:527–540PubMedGoogle Scholar
  26. Kendler K, Hewitt J (1992) The structure of self-report schizotypy in twins. J Personal Disord 6:1–17CrossRefGoogle Scholar
  27. Kendler KS, Ochs A, Gorman A, Hewitt J, Ross D, Mirsky A (1991) The structure of schizotypy: a multi-trait twin study. Psychiatry Res 36:19–36PubMedCrossRefGoogle Scholar
  28. Laurens KR, Hodgins S, Maughan B, Murray RM, Rutter ML, Taylor EA (2007) Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9–12 years. Schizophr Res. 90:130–146PubMedCrossRefGoogle Scholar
  29. Lenzenweger MF (2006) Schizotaxia, schizotypy, and schizophrenia: Paul E. Meehl’s blueprint for the experimental psychopathology and genetics of schizophrenia. J Abnorm Psychol 115(2):195–200PubMedCrossRefGoogle Scholar
  30. Lin CC, Su CH, Kuo PH, Hsiao CK, Soong WT, Chen WJ (2007) Genetic and environmental influences on schizotypy among adolescents in Taiwan: a multivariate twin/sibling analysis. Behav Genet 37(2):334–344PubMedCrossRefGoogle Scholar
  31. Linney YM, Murray RM, Peters ER, MacDonald AM, Rijsdijk F, Sham PC (2003) A quantitative genetic analysis of schizotypal personality traits. Psychol Med 33(5):803–816PubMedCrossRefGoogle Scholar
  32. Lykken (1978) The diagnosis of zygosity in twins. Behav Genet 8:437–473PubMedCrossRefGoogle Scholar
  33. MacDonald A III, Pogue-Geile MF, Debski TT, Manuck S (2001) Genetic and environmental influences on schizotypy: a community-based twin study. Schizophr Bull 27:47–58PubMedGoogle Scholar
  34. Mason O, Claridge G, Jackson M (1995) New scales for the assessment of schizotypy. Personal Individ Differ 18:7–13CrossRefGoogle Scholar
  35. Mason O, Linney Y, Claridge G (2005) Short scales for measuring schizotypy. Schizophr Res. 78:293–296PubMedCrossRefGoogle Scholar
  36. Mata I, Gilvarry CM, Jones PB, Lewis SW, Murray RM, Sham PC (2003) Schizotypal personality traits in nonpsychotic relatives are associated with positive symptoms in psychotic probands. Schizophr. Bull. 29:273–283PubMedGoogle Scholar
  37. Mata I, Mataix-Cols D, Peralta V (2005) Schizotypal Personality Questionnaire-Brief: factor structure and influence of sex and age in a nonclinical population. Personal. Individ. Diff. 38:1183–1192CrossRefGoogle Scholar
  38. Mata I, Sham PC, Gilvarry CM, Jones PB, Lewis SW, Murray RM (2000) Childhood schizotypy and positive symptoms in schizophrenic patients predict schizotypy in relatives. Schizophrenia Research 44:129–136PubMedCrossRefGoogle Scholar
  39. Meehl P (1989) Schizotaxia revisited. Arch Gen Psychiatry 46:935–944PubMedGoogle Scholar
  40. Miller MB (1993) A Study of Schizotypal Traits in Young Male Twins. Unpublished Ph.D. dissertation, University of Wisconsin, MadisonGoogle Scholar
  41. Miller MB (1994) A study of schizotypal traits in young male twins. Dissertation Abstracts International: Section B: The Sciences and Engineering 54, 5397-BGoogle Scholar
  42. Muthen, L.K & Muthen, B.O (1998–2007) Mplus User’s Guide. Muthen & Muthen, Los Angeles, CAGoogle Scholar
  43. Neale MC, Cardon LR (1992) Methodology for genetic studies of twins and families. Kluwer Academic Publications, Dordrecht, The NetherlandsGoogle Scholar
  44. Neale MC, Boker SM, Xie G, Maes H (2003) Mx: Statistical modeling. Department of Psychiatry, Medical College of Virginia, Richmond, VAGoogle Scholar
  45. Peters ER, Day S, Garety PA (1996) The Peters et al. Delusions Inventory (PDI): new norms for the 21-item version. Schizophr Res 18:118CrossRefGoogle Scholar
  46. Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H (2000) Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch. Gen. Psychiatry. 57:1053–1058PubMedCrossRefGoogle Scholar
  47. Raine A (1991) The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 17(4):555–564PubMedGoogle Scholar
  48. Raine A (1992) Sex differences in schizotypal personality in a non clinical population. J. Abnorm. Psychol. 101:361–364PubMedCrossRefGoogle Scholar
  49. Raine A, Baker LA (2003). The SPQ-C: a brief child verison of the Schizotypal Personality Questionnaire. Unpublished questionnaire, Department of Psychology, University of Southern CaliforniaGoogle Scholar
  50. Raine A, Benishay D (1995) The SPQ-B: a brief screening instrument for schizotypal personality disorder. J Personal Disord 9:346–355CrossRefGoogle Scholar
  51. Raine A, Reynolds C, Lencz T, Scerbo A, Triphon N, Kim D (1994) Cognitive-perceptual, interpersonal, and disorganized features of schizotypal personality. Schizophr Bull 20(1):191–201PubMedGoogle Scholar
  52. Reynolds CA, RaineA, Mellingen K, Venables PH, Mednick SA (2000) Three-factor model of schizotypal personality: invariance across culture, gender, religious affiliation, family adversity, and psychopathology. Schizophrenia Bull 603–618Google Scholar
  53. Rossi A, Daneluzzo E (2002) Schizotypal dimensions in normals and schizophrenic patients: A comparison with other clinical samples. Schizophrenia Research 54:67–75PubMedCrossRefGoogle Scholar
  54. SPSS Inc (1998) SPSS Base 8.0 for Windows User’s Guide. SPSS Inc., ChicagoGoogle Scholar
  55. Turetsky BI, Calkins ME, Light GA, Olincy A, Radant AD, Swerdlow NR (2007) Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophr Bull 33(1):69–94PubMedCrossRefGoogle Scholar
  56. Van den Oord EJ, Simonoff E, Eaves L, Pickles A, Silberg J, Maes H (2000) An evaluation of different approaches for behavior genetic analyses with psychiatric symptom scores. Behav Genet 30:1–18PubMedCrossRefGoogle Scholar
  57. Vollema MG, Hoijtink H (2000) The multidimensionality of self-report schizotypy in a psychiatric population: An analysis using multidimensional Rasch models. Schizophrenia Bulletin 26(3):565–575PubMedGoogle Scholar
  58. Vollema MG, Sitskoorn MM, Appels MCM, Kahn RS (2002) Does the Schizotypal Personality Questionnaire reflect the biological-genetic vulnerability to schizophrenia. Schizophrenia Research 54:39–45PubMedCrossRefGoogle Scholar
  59. Vollema MG, Van den Bosch RJ (1995) The multidimensionality of schizotypy. Schizophr Bull 21:19–32PubMedGoogle Scholar
  60. Walker EF, Bollini A (2002) Pubertal neurodevelopmental and the emergence of psychotic symptoms. Schizophr. Res. 54:17–23PubMedCrossRefGoogle Scholar
  61. Walker EF, Neumann CC, Baum K, Davis DM (1996) The developmental pathways to schizophrenia: potential moderating effects of stress. Dev Psychopathol. 8:647–665CrossRefGoogle Scholar
  62. Walker EF (2001) Adolescent changes in stress sensitivity and the expression of vulnerability to psychopathology. Development and Psychopathology. 13:721–732PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Marissa Ericson
    • 1
  • Catherine Tuvblad
    • 1
  • Adrian Raine
    • 2
  • Kelly Young-Wolff
    • 1
  • Laura A. Baker
    • 1
  1. 1.Department of Psychology (SGM 501)University of Southern CaliforniaLos AngelesUSA
  2. 2.Departments of Criminology, Psychiatry and PsychologyUniversity of PennsylvaniaPhiladelphiaUSA

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