Behavioral Differences Between C57BL/6J × FVB/NJ and C57BL/6J × NZB/B1NJ F1 Hybrid Mice: Relation to Control of Ethanol Intake
C57BL/6J × FVB/NJ F1 (B6 × FVB) mice consume more alcohol than C57BL/6J × NZB/B1NJ F1 (B6 × NZB) mice and this high alcohol consumption is stable after abstinence whereas B6 × NZB show reduced consumption, thus providing models of Sustained Alcohol Preference (SAP) and Reduced Alcohol Preference (RAP). In female hybrids, we assessed several behavioral responses to define behaviors which might predict SAP and RAP. B6 × FVB exhibited less severe ethanol-induced conditioned taste aversion and were less sensitive to ethanol-induced loss of righting reflex than B6 × NZB. Both hybrids demonstrated ethanol-induced place preference and a low ethanol withdrawal severity. We found that these hybrids differ in their sensitivity to the aversive and sedative, but not rewarding, effects of ethanol. Results of elevated plus maze, mirror chamber, and locomotor tests reveal B6 × FVB mice are less anxious and more active than B6 × NZB mice. Results obtained offer insights about factors that determine SAP and RAP in these new genetic models of alcohol consumption.
KeywordsAlcohol preference or consumption Hybrid Conditioned place preference Conditioned taste aversion Loss of righting reflex
- Fernández-Teruel A, Driscoll P, Gil L, Aguilar R, Tobeña A, Escorihuela RM (2002) Enduring effects of environmental enrichment on novelty seeking, saccharin and ethanol intake in two rat lines (RHA/Verh and RLA/Verh) differing in incentive-seeking behavior. Pharmacol Biochem Behav 73:225–231CrossRefPubMedGoogle Scholar
- Phillips TJ, Broadbent J, Burkhart-Kasch S, Henderson C, Wenger CD, McMullin C, McKinnon CS, Cunningham CL (2005) Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. Behav Neurosci 119:892–910CrossRefPubMedGoogle Scholar