Behavior Genetics

, Volume 38, Issue 3, pp 292–300

Divergent Physical Activity and Novel Alternative Responses to High Fat Feeding in Polygenic Fat and Lean Mice

  • Matjaž Simončič
  • Simon Horvat
  • Paula L. Stevenson
  • Lutz Bünger
  • Megan C. Holmes
  • Christopher J. Kenyon
  • John R. Speakman
  • Nicholas M. Morton
Original Research

DOI: 10.1007/s10519-008-9199-y

Cite this article as:
Simončič, M., Horvat, S., Stevenson, P.L. et al. Behav Genet (2008) 38: 292. doi:10.1007/s10519-008-9199-y

Abstract

We determined whether altered physical activity levels might underlie the contrasting adiposity of a divergently selected polygenic murine model of metabolic syndrome (Fat; F) and leanness (Lean; L) mice. We measured physical activity with a long term running wheel experiment and performed an additional high fat diet intervention. Further, we measured posture allocation by visual monitoring within the home cage as a non-exercise correlate of ‘normal’ physical activity. Whilst initially similar, running wheel activity of the F line declined with age, while the activity of the L line increased. Food intake was higher in the L line and increased with wheel exposure. Vertical rearing measured by video quantification in the home cage, without the stimulus of a running wheel was also significantly higher in the L line. The two lines developed novel alternate strategies to defend their body weight when exposed to high fat diets with a running wheel. F mice increased their running wheel activity, and despite unaltered food intake, still gained weight. L mice reduced their food intake and maintained activity levels without a significant change in body weight. Phenotypic selection for divergence in body fat content has co-segregated with a genetic predisposition for divergent physical activity levels and different strategies for coping with exposure to high fat diets that will facilitate the discovery of the genes underlying these important obesity related traits.

Keywords

Obesity Physical activity Running wheels Fat percentage Metabolic syndrome 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Matjaž Simončič
    • 1
    • 2
  • Simon Horvat
    • 1
  • Paula L. Stevenson
    • 3
  • Lutz Bünger
    • 4
  • Megan C. Holmes
    • 3
  • Christopher J. Kenyon
    • 3
  • John R. Speakman
    • 2
  • Nicholas M. Morton
    • 3
  1. 1.Biotechnical Faculty, Zootechnical DepartmentUniversity of LjubljanaDomzaleSlovenia
  2. 2.Aberdeen Centre for Energy Regulation and Obesity (ACERO), School of Biological SciencesUniversity of AberdeenAberdeenScotland, UK
  3. 3.Endocrinology Unit, Centre for Cardiovascular Sciences, Queens Medical Research InstituteUniversity of EdinburghEdinburghUK
  4. 4.Animal Breeding and Development Team, Sustainable Livestock Systems GroupSACPenicuik, MidlothianUK

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