Behavior Genetics

, Volume 36, Issue 6, pp 858–868

Speech Sound Disorder Influenced by a Locus in 15q14 Region

  • Catherine M. Stein
  • Christopher Millard
  • Amy Kluge
  • Lara E. Miscimarra
  • Kevin C. Cartier
  • Lisa A. Freebairn
  • Amy J. Hansen
  • Lawrence D. Shriberg
  • H. Gerry Taylor
  • Barbara A. Lewis
  • Sudha K. Iyengar
Original paper

Abstract

Despite a growing body of evidence indicating that speech sound disorder (SSD) has an underlying genetic etiology, researchers have not yet identified specific genes predisposing to this condition. The speech and language deficits associated with SSD are shared with several other disorders, including dyslexia, autism, Prader-Willi Syndrome (PWS), and Angelman’s Syndrome (AS), raising the possibility of gene sharing. Furthermore, we previously demonstrated that dyslexia and SSD share genetic susceptibility loci. The present study assesses the hypothesis that SSD also shares susceptibility loci with autism and PWS. To test this hypothesis, we examined linkage between SSD phenotypes and microsatellite markers on the chromosome 15q14–21 region, which has been associated with autism, PWS/AS, and dyslexia. Using SSD as the phenotype, we replicated linkage to the 15q14 region (P = 0.004). Further modeling revealed that this locus influenced oral-motor function, articulation and phonological memory, and that linkage at D15S118 was potentially influenced by a parent-of-origin effect (LOD score increase from 0.97 to 2.17, P = 0.0633). These results suggest shared genetic determinants in this chromosomal region for SSD, autism, and PWS/AS.

Keywords

Phonology Speech Language Parent-of-origin Allele-sharing 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Catherine M. Stein
    • 1
  • Christopher Millard
    • 1
  • Amy Kluge
    • 1
  • Lara E. Miscimarra
    • 1
  • Kevin C. Cartier
    • 1
  • Lisa A. Freebairn
    • 2
  • Amy J. Hansen
    • 2
  • Lawrence D. Shriberg
    • 3
  • H. Gerry Taylor
    • 2
  • Barbara A. Lewis
    • 2
  • Sudha K. Iyengar
    • 1
  1. 1.Department of Epidemiology and BiostatisticsCase Western Reserve UniversityClevelandUSA
  2. 2.Department of Pediatrics, Rainbow Babies & Childrens HospitalCase Western Reserve UniversityClevelandUSA
  3. 3.Waisman CenterUniversity of Wisconsin-MadisonMadisonUSA

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