Behavior Genetics

, Volume 36, Issue 4, pp 577–590

The Role of GABRA2 in Risk for Conduct Disorder and Alcohol and Drug Dependence across Developmental Stages

  • Danielle M. Dick
  • Laura Bierut
  • Anthony Hinrichs
  • Louis Fox
  • Kathleen K. Bucholz
  • John Kramer
  • Samuel Kuperman
  • Victor Hesselbrock
  • Marc Schuckit
  • Laura Almasy
  • Jay Tischfield
  • Bernice Porjesz
  • Henri Begleiter
  • John NurnbergerJr.
  • Xiaoling Xuei
  • Howard J. Edenberg
  • Tatiana Foroud
Article

DOI: 10.1007/s10519-005-9041-8

Cite this article as:
Dick, D.M., Bierut, L., Hinrichs, A. et al. Behav Genet (2006) 36: 577. doi:10.1007/s10519-005-9041-8

 

We use findings from the behavior genetics literature about how genetic factors (latently) influence alcohol dependence and related disorders to develop and test hypotheses about the risk associated with a specific gene, GABRA2, across different developmental stages. This gene has previously been associated with adult alcohol dependence in the Collaborative Study of the Genetics of Alcoholism (COGA) sample [Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R., Goate, A., Hesselbrock, V., Jones, K. A., Kwon, J., Li, T. K., Nurnberger Jr., J. I., O’Connor, S. J., Reich, T., Rice, J., Schuckit, M., Porjesz, B., Foroud, T., and Begleiter, H. (2004). Am. J. Hum. Genet74:705–714] and other studies [Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., and Kranzler, H. R. (2004). Am. J. Med. Genet. B Neuropsychiatr. Genet129B:104–109; Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L. K., Covault, J., Kranzler, H. R., Krystal, J., and Gelernter, J. (2005). Alcohol. Clin. Exp. Res29:493–498]. In a sample of children and adolescents ascertained as part of the COGA project, we find that GABRA2 is significantly associated with childhood conduct disorder symptoms, but not with childhood alcohol dependence symptoms. A consistent elevation in risk for alcohol dependence associated with GABRA2 is not evident until the mid-20s and then remains throughout adulthood. GABRA2 is also associated with other drug dependence in our sample, both in adolescence and adulthood.

Keywords

Alcohol conduct disorder dependence drug GABA substance use 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Danielle M. Dick
    • 1
    • 9
  • Laura Bierut
    • 1
  • Anthony Hinrichs
    • 1
  • Louis Fox
    • 1
  • Kathleen K. Bucholz
    • 1
  • John Kramer
    • 2
  • Samuel Kuperman
    • 2
  • Victor Hesselbrock
    • 3
  • Marc Schuckit
    • 4
  • Laura Almasy
    • 5
  • Jay Tischfield
    • 6
  • Bernice Porjesz
    • 7
  • Henri Begleiter
    • 7
  • John NurnbergerJr.
    • 8
  • Xiaoling Xuei
    • 8
  • Howard J. Edenberg
    • 8
  • Tatiana Foroud
    • 8
  1. 1.Department of Psychiatry and PsychologyWashington University School of MedicineSt. LouisUSA
  2. 2.University of Iowa School of MedicineIowa CityUSA
  3. 3.University of Connecticut School of MedicineFarmingtonUSA
  4. 4.University of California at San Diego School of MedicineLa JollaUSA
  5. 5.Southwest FoundationSan AntonioUSA
  6. 6.Rutgers UniversityPiscatawayUSA
  7. 7.SUNY Health Science Center at BrooklynBrooklynUSA
  8. 8.Indiana University School of MedicineIndianapolisUSA
  9. 9.WUSM PsychiatrySt. LouisUSA

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