Behavior Genetics

, 36:65 | Cite as

Cognitive Traits Link to Human Chromosomal Regions

  • Steven Buyske
  • Marsha E. Bates
  • Neda Gharani
  • Tara C. Matise
  • Jay A. Tischfield
  • Paul Manowitz
Article

 

Human cognition in normal and disease states is both environmentally and genetically mediated. Except for measures of language-specific abilities, however, few cognitive measures have been associated with specific genes or chromosomal regions. We performed genome-wide linkage analysis of five neuropsychological tests in the Collaborative Study on Genetics of Alcoholism sample. The sample included 1579 individuals (53% female, 76% White Non-Hispanic) in 217 families. There were 390 markers with mean intermarker distance of 9.6 cM. Performance on the Digit Symbol Substitution Test, a component of the Wechsler Adult Intelligence Scale-R, showed significant linkage to 14q11.2 and suggestive linkage to 14q24.2. This test of sustained visual attention also involves visual-motor coordination and executive functions. Performance on the WAIS-R Digit Span Test of immediate memory and mental flexibility showed suggestive linkage to 11q25. Although the validity of these results beyond populations with a susceptibility for alcohol dependence is unclear, these results are among the first linkage results for non-language components of cognition.

Keywords

Cognitive trait Digit Span Digit Symbol genetic linkage quantitative trait loci Wechlser Adult Intelligence Scale-R 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Steven Buyske
    • 1
    • 2
    • 3
    • 6
  • Marsha E. Bates
    • 2
    • 5
  • Neda Gharani
    • 3
  • Tara C. Matise
    • 3
  • Jay A. Tischfield
    • 2
    • 3
    • 4
    • 5
  • Paul Manowitz
    • 2
    • 5
  1. 1.Department of StatisticsRutgers UniversityPiscatawayUSA
  2. 2.Center of Alcohol StudiesRutgers UniversityPiscatawayUSA
  3. 3.Department of GeneticsRutgers UniversityPiscatawayUSA
  4. 4.Department of PediatricsUniversity of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical SchoolPiscatawayUSA
  5. 5.Department of PsychiatryUniversity of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical SchoolPiscatawayUSA
  6. 6.Department of StatisticsRutgers UniversityPiscatawayUSA

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