Behavior Genetics

, Volume 35, Issue 5, pp 579–590 | Cite as

Genetic Effects on Physical Health: Lower at Higher Income Levels

Article

Given the robust finding that people in higher income groups tend to experience better physical health, there is interest in identifying mechanisms underlying this gradient. Using a nationwide sample of 719 twin pairs from the National Survey of Midlife Development in the United States, we investigated the possibility that gene-environment interaction underlies the income-health gradient. We observed that genetic variance associated with 2 measures of physical health, number of chronic illnesses and body mass index, each declined significantly with increasing income. This interaction effect could not be removed by adjusting income for the presence of health insurance coverage and education, suggesting that the interaction is not simply a result of differences in levels of those characteristics with income.

Keywords

Environmental influences genetic influences income physical health twin study 

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References

  1. Adler, N. E., Boyce, T., Chesney, M. A., Cohen, S., Folkman, S., Kahn, R. L., Syme, S. L. 1994Socioeconomic status and healthAm. Psychol.491524CrossRefPubMedGoogle Scholar
  2. Adler, N. E., Epel, E. S., Castellazzo, G., Ickovics, J. R. 2000Relationship of subjective and objective social status with psychological and physiological functioning: Preliminary data in healthy white womenHealth Psychol.19586592CrossRefPubMedGoogle Scholar
  3. Adler, N. E., Snibbe, A. C. 2003The role of psychosocial processes in explaining the gradient between socioeconomic status and healthCurr. Directions Psychol. Sci.12119123CrossRefGoogle Scholar
  4. Akaike, H. 1983Information measures and model selectionBull. Int. Stat. Inst.50277290Google Scholar
  5. Antonovsky, A. 1967Social class, life expectancy and overall mortalityMillbank Memorial Fund Quart.XLV3173Google Scholar
  6. Bailis, D. S., Segall, A., Mahon, M. J., Chipperfield, J. G., Dunn, E. M. 2001Perceived control in relation to socioeconomic and behavioral resources for healthSocial Sci. Med.5216611676CrossRefGoogle Scholar
  7. Christensen, L., Frederiksen, H., Schousboe, K., Skytthe, A., Wurmb-Schwark, N., Christensen, K., Kyvik, K. 2003Age- and sex-differences in the validity of questionnaire-based zygosity in twinsTwin Res.6275278CrossRefPubMedGoogle Scholar
  8. Fiscella, K., Franks, P. 1997Does psychological distress contribute to racial and socioeconomic disparities in mortalitySocial Sci. Med.4518051809CrossRefGoogle Scholar
  9. Gallo, L. C., Mathews, K. A. 2003Understanding the association between socioeconomic status and physical health: Do negative emotions play a role?Psychol. Bull.1291051CrossRefPubMedGoogle Scholar
  10. Gump, B. B., Matthews, K. A., Raikkonen, K. 1999Modeling relationships among socioeconomic status, hostility, cardiovascular reactivity, and left ventricular mass in African American and white childrenHealth Psychol.18140150CrossRefPubMedGoogle Scholar
  11. Harris, J. R., Pedersen, N. L., Stacey, C., McClearn, G. E., Nesselroade, J. R. 1992Age differences in the etiology of the relationship between life satisfaction and self-rated healthJ. Aging Health4349368Google Scholar
  12. Idler, E. L., Hudson, S. V., Leventhal, H. 1999The meanings of self-ratings of health: A quantitative and qualitative approachRes. Aging21458476Google Scholar
  13. Jylha, M. 1994Self-rated health revisited: Exploring survey interview episodes with elderly respondentsSocial Sci. Med.39983990CrossRefGoogle Scholar
  14. Karlamangla, A. S., Singer, B. H., McEwen, B. S., Rowe, J. W., Seeman, T. E. 2002Allostatic load as a predictor of functional decline: MacArthur studies of successful agingJ. Clin. Epidemiol.55696710CrossRefPubMedGoogle Scholar
  15. Kendler, K. S., Thornton, L. M., Gilman, S. E., Kessler, R. C. 2000Sexual orientation in a US national sample of twin and sibling pairsAm. J. Psychiat.15718431846CrossRefPubMedGoogle Scholar
  16. Kessler, R. C., Gilman, S. E., Thornton, L. M., and Kendler, K. S. (2004). Health, wellbeing, and social responsibility in the MIDUS twin and sibling subsamples. In O. G. Brim, C. D. Ryff and R. C. Kessler (eds.),How Healthy Are We? A National Study of Wellbeing at Midlife. Chicago: University of Chicago Press.Google Scholar
  17. Komaroff , A. L. eds. 1999Harvard Medical School Family Medical GuideSimon & SchusterNew YorkGoogle Scholar
  18. Krause, N. M., Jay, G. M. 1994What do global self-rated health items measure?Med. Care32930942PubMedGoogle Scholar
  19. Lachman, M. E., Weaver, S. L. 1998The sense of control as a moderator of social class differences in health and well-beingJ. Pers. Social Psychol.74763773CrossRefGoogle Scholar
  20. Lykken, D. T., Bouchard, T. J., McGue, M., Tellegen, A. 1990The Minnesota Twin Family Registry: Some initial findingsActa Genetica Medica Gemellol393570Google Scholar
  21. Marmot, M. G., Smith, G. D., Stansfield, S., Patel, C., Head, J., White, I., Brunner, E., Feeney, A. 1991Health inequalities among British civil servants: The Whitelhall II studyLancet33713871393CrossRefPubMedGoogle Scholar
  22. McEwen, B. S. 1998Protective and damaging effects of stress mediatorsN Engl. J. Med.338171179CrossRefPubMedGoogle Scholar
  23. McGue, M., Bouchard, T. J.,Jr. 1984Adjustment of twin data for the effects of age and sexBehav. Genet.14325343CrossRefPubMedGoogle Scholar
  24. Neale, M. C., Boker, S., Xie, G., Maes, H. H. 1999Mx: Statistical ModelingMedical College of Virginia Department of PsychiatryRichmond, VAGoogle Scholar
  25. Parsons, P. A. 2002Aging: The fitness-stress continuum and genetic variabilityExp. Aging Res.28347359CrossRefPubMedGoogle Scholar
  26. Parsons, P. A. 2003From the stress theory of aging to energetic and evolutionary expectations for longevityBiogerontology46373CrossRefPubMedGoogle Scholar
  27. Pauzova, Z., Sedova, L., Berube, J., Hamet, P., Tremblay, J., Dumont, M., Gaudet, D., Pravenec, M., Kren, V., Kunes, J. 2003Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressureHypertension4110471055CrossRefPubMedGoogle Scholar
  28. Purcell, S. 2002Variance component models for gene-environment interaction in twin analysisTwin Res.5554571CrossRefPubMedGoogle Scholar
  29. Roberts, G. 1999Age effects and health appraisal: A meta-analysisJ. Gerontol.54BS24S30Google Scholar
  30. Singer, B. H., Ryff, C. D. 1999

    Hierarchies of life histories and associated risks

    Adler, N. E.Marmot, M.McEwen, B. S.Stewart, J. eds. Socioeconomic Status and Health in Industrial NationsNew York Academy of SciencesNew York96115
    Google Scholar
  31. Stratton, D. A. 1998Reaction norm functions and QTL-environment interactions for flowering time in Arapidopsis thalianaHeredity81144155PubMedGoogle Scholar
  32. Strawbridge, W., Wallhagen, M. I. 1999Self-rated health and mortality over three decadesRes. Aging21402416Google Scholar
  33. Tiret, L. 2002Gene-environment interaction: a central concept in multifactorial diseasesProc. Nutr. Soc.61457463CrossRefPubMedGoogle Scholar
  34. Weiss, E. P., Brown, M. D., Shuldiner, A. R., Hagberg, J. M. 2002Fatty acid binding protein-2 gene variants and insulin resistance: gene and gene-environment interaction effectsPhysiol. Genomics10145157PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of Minnesota – Twin CitiesMinneapolisUSA

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