Behavior Genetics

, Volume 35, Issue 3, pp 359–368

Testosterone and Alcohol Use among Adolescent Male Twins: Testing Between-Family Associations in Within-Family Comparisons

  • C. J. Peter Eriksson
  • Jaakko Kaprio
  • Lea Pulkkinen
  • Richard J. Rose
Article

We examined associations of testosterone (T) and alcohol use in adolescent twin brothers, conducting both between- and within-family analyses. The twins completed semi-structured interviews, provided two saliva samples to assay T, and reported their drinking patterns and pubertal development. We adjusted T levels for diurnal/seasonal effects and association with pubertal maturation. In analyses of twins as individuals, higher T levels characterized boys reporting ever drinking, more frequent intoxication, high density drinking, more alcohol symptoms, and diagnosed alcohol dependency on interview. Adjusting for pubertal development, only associations with symptom count and diagnosis remained significant. The association with frequent intoxication replicated among drinking-discordant twin brothers, effectively ruling out between-family confounds, but that association was not significant after adjustment for pubertal development. The phenotypic correlation between T and pubertal maturation is largely genetic, inviting study of the magnitude and meaning of linkages between testosterone and symptoms of alcoholism on follow-up in early adulthood.

KEY WORDS:

Adolescent alcohol abuse pubertal development testosterone twin brothers 

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References

  1. Apter, S. J., Eriksson, C. J. P. 2003The effect of alcohol on testosterone concentrations in alcohol-preferring and non-preferring rat linesAlcohol. Clin. Exp. Res2711901193PubMedGoogle Scholar
  2. Archer, J. 1991The influence of testosterone on human aggressionBr. J. Psychol82128PubMedGoogle Scholar
  3. Archer, J. 1994Testosterone and aggressionJ. Offenders Rehab21339Google Scholar
  4. Booth, A., Johnson, D. R., Granger, D. A., Crouter, A. C., McHale, S. 2003Testosterone and child and adolescent adjustment: the moderating role of parent-child relationshipsDev. Psychol398598PubMedGoogle Scholar
  5. Caspi, A., Moffitt, T. E., Newman, D. L., Silva, P. A. 1996Behavioral observations at age 3 years predict adult psychiatric disorders: Longitudinal evidence from a birth cohortArch. Gen. Psychiatr5310331039PubMedGoogle Scholar
  6. Constantino, J. N., Grosz, D., Saenger, P., Chandler, D. W., Nandi, R., Earls, F. J. 1993Testosterone and aggression in childrenJ. Am. Acad. Child. Adolesc. Psyc3212171222CrossRefGoogle Scholar
  7. Dabbs, J. M.,Jr. 1990Salivary testosterone measurements: reliability across hours, days, and weeksPhysiol. Behav.488386PubMedGoogle Scholar
  8. Dabbs, J. M. 1991Salivary testosterone measurement: collecting, storing, and mailing saliva samplesPhysiol. Behav.49815817PubMedGoogle Scholar
  9. Dabbs, J. M.,Jr., Carr, T. S., Frady, R. L., Riad, J. K. 1995Testosterone, crime, and misbehavior among 692 male prison inmatesPerson. Individ. Diff18627633Google Scholar
  10. Dabbs, J. M.,Jr., Frady, R. L., Carr, T. S., Besch, N. F. 1987Saliva testosterone and criminal violence in young adult prison inmatesPsychosomat. Med49174182Google Scholar
  11. Dabbs, J. M.,Jr., Hopper, C. H., Jurkovic, G. J. 1990Testosterone and personality among college students and military veteransPerson. Individ. Diff1112631269Google Scholar
  12. Dabbs, J. M., Morris, R. 1990Testosterone, social class, and antisocial behavior in a sample of 4462 menPsychol. Sci1209211Google Scholar
  13. Dick, D. M., Rose, R. J., Pulkkinen, L., Kaprio, J. 2001Measuring puberty and understanding its impact: a longitudinal study of adolescent twinsJ. Youth Adolesc30385399Google Scholar
  14. Dick, D. M., Johnson, J. L., Viken, R. J., Rose, R. J. 2000Testing between-family associations in within-family comparisonsPsychol. Sci11409413PubMedGoogle Scholar
  15. Eaves, L. J., Silberg, J. L. 2003Modulation of gene expression by genetic and environmental heterogeneity in timing of a developmental milestoneBehav. Genet3316PubMedGoogle Scholar
  16. El-Migdady, F., Nusier, M., Bashir, N. 2000Seasonal pattern of leutinizing, follicle-stimulating hormone, testosterone and progesterone in adult population of both sexes in the Jordan ValleyEndocrinol. Res264148CrossRefGoogle Scholar
  17. Fergusson, D. M., Horwood, L. J., Lynskey, M. D. 1995The prevalence and risk factors associated with abusive or hazardous alochol consumption in 16-year-oldsAddiction90935946PubMedGoogle Scholar
  18. Harris, J. A., Vernon, P. A., Boomsma, D. I. 1998The heritability of testosterone: a study of Dutch adolescent twins and their parentsBehav. Genet28165171PubMedGoogle Scholar
  19. Inoff-Germain, F., Arnold, G., Nottelmann, E., Sussman, E., Cutler, G., Chrouses, G. 1988Relations between hormone levels and observational measures of aggressive behavior of young adolescents in family interactionsDev. Psychol24129139Google Scholar
  20. Kaprio, J. K., Pulkkinen, L., Rose, R. J. 2002Genetic and environmental factors in health-related behaviors: studies on Finnish twins and their familiesTwin Res5366371PubMedGoogle Scholar
  21. Kuperman, S., Schlosser, S. S., Kramer, J. R., Bucholz, K., Hesselbrock, V., Reich, T., Reich, W. 2001Risk domains associated with an adolescent alcohol dependence diagnosisAddiction96629636PubMedGoogle Scholar
  22. La Grange, L., Jones, T. D., Erb, L., Reyes, E. 1995Alcohol consumption: Biochemical and personality correlates in a college student populationAddict. Behav2093103PubMedGoogle Scholar
  23. Martin, C. A., Mainous, A. G.,III, Curry, T., Martin, D. 1999Alcohol use in adolescent females: correlates with estradiol and testosteroneAm. J. Addictions8914Google Scholar
  24. Olweus, D., Mattsson, Å., Schalling, D., Lö, H. 1980Testosterone, aggression, physical and personality dimensions in normal adolescent malesPsychosom. Med42253269PubMedGoogle Scholar
  25. Olweus, D., Mattsson, Å., Schalling, D., Lö, H. 1988Circulating testosterone levels in aggression in adolescent males: A causal analysisPsychosom. Med50261272PubMedGoogle Scholar
  26. Petersen, A. C., Tobin-Richards, M., Boxer, A. 1983Puberty: its measurement and its meaningJ. Early Adolesc.34762Google Scholar
  27. Petersen, A. C., Crockett, L., Richards, M., Boxer, A. 1988A self-report measure of pubertal status: reliability, validity, and initial normsJ. Youth Adolesc17117133Google Scholar
  28. Pulkkinen, L., Pitkänen, T. A. 1994Prospective study of the precursors to problem drinking in young adulthoodJ. Stud. Alcohol55578587PubMedGoogle Scholar
  29. Rose, R. J. 1998A developmental behavior-genetic perspective on alcoholism riskAlcohol Health Res. W22131143Google Scholar
  30. Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., Kaprio, J. 2001Drinking or abstaining at age 14? A genetic epidemiological studyAlcoholism Clin. Exp. Res2515941604Google Scholar
  31. Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., Kaprio, J. 2004Genetic and environmental effects on conduct disorder, alcohol symptoms, and their covariation at age 14Alcoholism Clin. Exp. Res.2815411548Google Scholar
  32. Rowe, R., Maughan, B., Worthman, C. M., Costello, E. J., Angold, A. 2004Testosterone, antisocial behavior, and social dominance in boys: pubertal development and biosocial interactionBiol. Psychiatr55546552Google Scholar
  33. Saccone, N. L., Kwon, J. M., Corbett, J., Goate, A., Rochberg, N., Edenberg, H. J., Foroud, T., Li, T. K., Begleiter, H., Reich, T., Rice, J. P. 2000A genome screen of maximum number of drinks as an alcoholism phenotypeAm. J. Med.Genet96632637PubMedGoogle Scholar
  34. Stata Corporation2001Stata statistical software, release 7.0Stata CorporationCollege Station, TXGoogle Scholar
  35. Susman, E., Inoff-Germain, G., Nettelmann, E., Loriaux, D., Cutler, G., Chrousos, G. 1987Hormones, emotional dispositions, and aggressive attributions in young adultsChild Dev5811141134PubMedGoogle Scholar
  36. Tremblay, R. E., Loeber, R., Gagnon, C., Charlebois, P., Larivée, S., LeBlanc, M. 1991Disruptive boys with stable and unstable high fighting behavior patterns during junior elementary schoolJ. Abnor. Child Psychol19285300Google Scholar
  37. Tremblay, R. E., Schaal, B., Boulerice, B., Arseneault, L., Soussignan, R. G., Paquette, D., Laurent, D. 1998Testosterone, physical aggression, dominance, and physical development in early adolescenceInt. J. Behav. Dev22753777Google Scholar
  38. Virkkunen, M., Rawlings, R., Tokola, R., Poland, R. E., Guidott, A., Nemeroff, C., Bisset, G. 1994CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteersArch. Gen. Psychiatr512027PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • C. J. Peter Eriksson
    • 1
  • Jaakko Kaprio
    • 1
    • 2
  • Lea Pulkkinen
    • 3
  • Richard J. Rose
    • 2
    • 4
  1. 1.Department of Mental Health and Alcohol ResearchNational Public Health InstituteHelsinkiFinland
  2. 2.Department of Public Health ScienceUniversity of HelsinkiFinland
  3. 3.Department of PsychologyUniversity of JyväskyläFinland
  4. 4.Department of PsychologyIndiana UniversityBloomingtonUSA

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