We studied the effectiveness of anti-tuberculosis vaccination with BCG in mice of inbred strains and F1 hybrids (highly resistant to tuberculosis infection) that represent a wide range of genetically determined differences in susceptibility to infection with virulent Mycobacterium tuberculosis. The greatest relative effect was found in susceptible mice, with the exception of highly susceptible I/St mice that were practically not protected by vaccination. Despite significant effect of vaccination in inbred mice, their resistance to M. tuberculosis infection did not exceed that of non-vaccinated highly resistant F1 hybrids.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 4, pp. 453-457, April, 2021
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Nikonenko, B.V., Logunova, N.N., Sterzhanova, N.V. et al. Efficacy of BCG Vaccination Depends on Host Genetics. Bull Exp Biol Med 171, 445–448 (2021). https://doi.org/10.1007/s10517-021-05246-9
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DOI: https://doi.org/10.1007/s10517-021-05246-9