Serotonin-Containing Cells in the Primary Organ of Hemopoiesis after Autologous Bone Marrow Transplantation

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Serotonin-containing cytostructures of mouse bone marrow after autotransplantation were studied using Falk—Hillarp luminescent histochemical method, and expression of antiapoptotic marker was determined by the immunohistochemical reaction. Autotransplantation of the bone marrow in mice led to an increase in the number of mast cells; in 40 and 120 min after autotransplantation, serotonin content in mast cells increased by 12 and 23%, respectively, and in hemopoietic cells of the bone marrow — by 24 and 78%, respectively, which affected the early stages of proliferation and differentiation of hemopoietic cells. The mitotic index in bone marrow smears at these terms increased by 3.8 and 4.5 times. According to myelogram data, the fraction of early undifferentiated forms (lymphoblasts, erythroblasts) in the primary organ of hemopoiesis (bone marrow) increased.

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Correspondence to O. V. Vorob’yova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 9, pp. 355-358, September, 2019

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Vorob’yova, O.V., Lubovtseva, L.A. & Guryanova, E.A. Serotonin-Containing Cells in the Primary Organ of Hemopoiesis after Autologous Bone Marrow Transplantation. Bull Exp Biol Med 168, 381–384 (2020).

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Key Words

  • bone marrow
  • mast cells
  • serotonin