Serotonin-containing cytostructures of mouse bone marrow after autotransplantation were studied using Falk—Hillarp luminescent histochemical method, and expression of antiapoptotic marker was determined by the immunohistochemical reaction. Autotransplantation of the bone marrow in mice led to an increase in the number of mast cells; in 40 and 120 min after autotransplantation, serotonin content in mast cells increased by 12 and 23%, respectively, and in hemopoietic cells of the bone marrow — by 24 and 78%, respectively, which affected the early stages of proliferation and differentiation of hemopoietic cells. The mitotic index in bone marrow smears at these terms increased by 3.8 and 4.5 times. According to myelogram data, the fraction of early undifferentiated forms (lymphoblasts, erythroblasts) in the primary organ of hemopoiesis (bone marrow) increased.
This is a preview of subscription content, log in to check access.
Buy single article
Instant unlimited access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Afanas’eva MA, Izvol’skaya MS, Voronova SN, Zakharova LA, Melnikova VI. Effect of serotonin deficiency on the immune system development in the rat. Dokl. Biol. Sci. 2009;427(1):319-321.
Vorob’eva OV. Dynamics of the Morphofunctional State of Bone Marrow Cell-Differons as a Hematopoietic Organ. Zh. Anat. Gistopatol. 2017;6(2):26-29. Russian.
Vorobeva ÜV, Lyubovtseva LA. Impact on geterotransplantation neyroamine in structures marrow. Morfol. Vedomosti. 2015;(4):54-58. Russian.
Gur’yanova EA, Lyubovtseva LA, Filonenko AV. Interaction of neurotransmitter-containing structures of the skin and thymus during acupuncture. Traditsionnaya Meditsina. 2009;(4):46-48. Russian.
Krotkova OS, Gurianova EA, Nikolayeva SV, Lubovtseva LA, Alekseyeva LA, Kashkirov VV. Luminescent-morphological features of mouse spleen after acupuncture. Bull. Exp. Biol. Med. 2014;157(6):791-795. doi: https://doi.org/10.1007/s10517-014-2674-y
Mel’nikova VI, Isvol’skaya MS, Voronova SN, Zakharova LA. The role of serotonin in the immune system development and functioning during ontogenesis. Biol. Bull. 2012;39(3):237-243.
Guideline for Laboratory Animals and Alternative Models in Biomedical Technologies. Karkishchenko NN, Grachev SV, eds. Moscow, 2010. Russian.
Sepiashvili RI, Balmasova IP, Staurina LN. Serotonin and its immunophysiological effects. Allergol. Immunol. 2015;16(1):169-178. Russian.
Bulfone-Paus S, Bahri R. Mast cells as regulators of T cell responses. Front. Immunol. 2015;6. ID 394. doi: https://doi.org/10.3389/fimmu.2015.00394
Côté F, Vaillancourt C. 70 years of serotonin. Biochimie. 2019;161:1-2. doi: https://doi.org/10.1016/j.biochi.2019.04.012
da Silva E, Jamur M, Oliver C. Mast cell function: a new vision of an old cell. J. Histochem. Cytochem. 2014;62(10):698-738.
Goldberg JD, Zheng J, Ratan R, Small TN, Lai KC, Boulad F, Castro-Malaspina H, Giralt SA, Jakubowski AA, Kernan NA, O’Reilly RJ, Papadopoulos EB, Young JW, van den Brink MR, Heller G, Perales MA. Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant. Leuk. Lymphoma. 2017;58(8):1859-1871.
Xu L, Cai Z, Yang F, Chen M. Activation-induced upregulation of MMP9 in mast cells is a positive feedback mediator for mast cell activation. Mol. Med. Rep. 2017;15(4):1759-1764.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 9, pp. 355-358, September, 2019
About this article
Cite this article
Vorob’yova, O.V., Lubovtseva, L.A. & Guryanova, E.A. Serotonin-Containing Cells in the Primary Organ of Hemopoiesis after Autologous Bone Marrow Transplantation. Bull Exp Biol Med 168, 381–384 (2020). https://doi.org/10.1007/s10517-020-04714-y
- bone marrow
- mast cells