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Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 3, pp 349–351 | Cite as

New Combined Eye Gel with Alpha-2-Beta Interferon

  • M. N. AnurovaEmail author
  • E. O. Bakhrushina
  • I. V. Lapik
  • A. S. Kashperko
  • I. I. Krasnyuk
NEW DRUGS

The results of the development of combined eye gel with interferon alpha-2-beta are presented. Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated. The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.

Key Words

ophthalmic gel interferon alfa-2-beta dalargin cytotoxicity bioadhesion 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • M. N. Anurova
    • 1
    Email author
  • E. O. Bakhrushina
    • 1
  • I. V. Lapik
    • 1
  • A. S. Kashperko
    • 1
  • I. I. Krasnyuk
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical UniversityMinistry of Health of the Russian Federation (Sechenov University)MoscowRussia

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