Perfluoroisobutylene a is pulmonotoxic chemical generated during pyrolysis of perfluoro-nalkanes (polytetrafluoroethylene). The mechanisms of acute pulmonary toxicity induced by perfluoroisobutylene have not been studied yet. The analysis of tissues of brown frogs showed that the products of polytetrafluoroethylene pyrolysis induce typical inflammatory response in the lungs (fluid accumulation, erythrocyte stasis, desquamation of the epithelium, and capillary plethora in lung septa) and oropharyngeal cavity (degeneration of ciliated epithelium, hyperemia of underlying vessels with plasmatic imbibition of the connective tissue, and margination of segmented leukocytes and monocytes). The absence of surfactant is a specific feature of the blood—air barrier of the oropharyngeal cavity in frogs compared to the lungs. It can be hypothesized that toxic effects of perfluoroisobutylene are determined by its influence on epithelial (pneumocytes and cells of nonkeratinized stratified ciliated epithelium) and endothelial cells. Even though the effects of the agent on surfactant cannot be excluded, they do not determine the probability of development of inflammatory response.
This is a preview of subscription content, log in to check access.
Buy single article
Instant unlimited access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Dzerzhinskii FYa. Comparative Anatomy of Vertebrates: a Textbook for University Students. Moscow, 2005. Russian.
Respiratory System (Histophysiology, Evolution, Biochemistry, Pathology and Treatment of Bronchial Asthma): Textbook. Blagoveshchensk, 2010. Russian.
Romer AS, Parsons TS. The Vertebrate Body. Vol. 2. Moscow, 1992. Russian.
Ecological Physiology of Animals: Physiological Systems during Adaptation and Environmental Factors. Moscow, 1981. P. 246. Russian.
Brown RF, Rice P. Electron microscopy of rat lung following a single acute exposure to perfluoroisobutylene (PFIB). A sequential study of the first 24 hours following exposure. Int. J. Exp. Pathol. 1991;72(4):437-450.
Jugg B, Jenner J, Rice P. The effect of perfluoroisobutene and phosgene on rat lavage fluid surfactant phospholipids. Hum. Exp. Toxicol. 1999;18(11):659-668.
Meng G, Zhao J, Wang HM, Ding RG, Zhang XC, Huang CQ, Ruan JX. Injury of cell tight junctions and changes of actin level in acute lung injury caused by the perfluoroisobutylene exposure and the role of Myosin light chain kinase. J. Occup. Health. 2011;53(4):250-257.
Tsai WT. Environmental hazards and health risk of common liquid perfluoro-n-alkanes, potent greenhouse gases. Environ. Int. 2009;35(2):418-424.
Zhang Y, Fan L, Xi R, Mao Z, Shi D, Ding D, Zhang Z, Wang X. Lethal concentration of perfluoroisobutylene induces acute lung injury in mice mediated via cytokine storm, oxidative stress and apoptosis. Inhal. Toxicol. 2017;29(6):255-265.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 9, pp. 313-317, September, 2019
About this article
Cite this article
Tolkach, P.G., Basharin, V.A., Chepur, S.V. et al. Mechanisms of Pulmonary Toxicity of Perfluoro-n-Alkane Pyrolysis Products with Consideration of the Structural Features of the Blood—Air Barriers. Bull Exp Biol Med 168, 345–348 (2020) doi:10.1007/s10517-020-04705-z
- perfluoroisobutylene-induced acute lung injury
- blood—air barrier