Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus
We analyzed the effects of intranasal administration of insulin (0.48 U/rat) and gangliosides (6 mg/kg) on spatial memory in rats with the neonatal model of the type 2 diabetes mellitus. The development of diabetes was verified by the glucose tolerance test. Insulin and gangliosides improved training and reversal training in diabetic rats in a modified version of Morris water maze test and reduced the time of finding the hidden platform. High effectiveness of intranasal administration of gangliosides to animals for the normalization of cognitive functions was shown for the first time. The effects of insulin and gangliosides were similar during training, but during reversal training, gangliosides were more effective. At the same time, intranasally administered insulin, unlike gangliosides, partially normalized glucose tolerance in rats with type 2 diabetes mellitus.
Key Wordstype 2 diabetes mellitus spatial memory gangliosides intranasal administration
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- 2.Shpakov AO, Derkach KV. Brain Hormone Systems and Type 2 Diabetes Mellitus. St. Petersburg, 2015. Russian.Google Scholar
- 3.Avrova NF, Victorov IV, Tyurin VA, Zakharova IO, Sokolova TV, Andreeva NA, Stelmaschuk EV, Tyurina YY, Gonchar VS. Inhibition of glutamate-induced intensification of free radical reactions by gangliosides: possible role in their protective effect in rat cerebellar granule cells and brain synaptosomes. Neurochem. Res. 1998;23(7):945-952.CrossRefGoogle Scholar
- 4.Derkach K, Zakharova I, Zorina I, Bakhtyukov A, Romanova I, Bayunova L, Shpakov A. The evidence of metabolic-improving effect of metformin in Ay/a mice with geneticallyinduced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect. PLoS One. 2019;14(3). ID e0213779. doi: https://doi.org/10.1371/journal.pone.0213779 CrossRefGoogle Scholar