Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 3, pp 313–316 | Cite as

rs11927381 Polymorphism and Type 2 Diabetes Mellitus: Contribution of Smoking to the Realization of Susceptibility to the Disease

  • I. E. AzarovaEmail author
  • E. Yu. Klyosova
  • V. A. Lazarenko
  • A. I. Konoplya
  • A. V. Polonikov

In the study that included 579 patients with type 2 diabetes mellitus and 542 healthy individuals from Slavonic population, an association was found between IGF2BP2 gene rs11927381 polymorphism and increased risk of developing the disease. However, this association was observed for smoking patients and was not detected for non-smokers. Bioinformatics analysis showed that the spectrum of transcription factors binding with high-risk C allele differ from the spectrum of transcription factors specifically binding with the reference T allele; these factors are involved in the regulation of the biosynthesis of ketone bodies and cellular response to glucocorticoid hormones. The results suggest that smoking plays a trigger role in the relationship of the polymorphic variant rs11927381 of the IGF2BP2 gene with the development of type 2 diabetes mellitus.

Key Words

type 2 diabetes smoking single nucleotide polymorphism IGF2BP2 transcription factors 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ametov AS, Solov’eva OL. Oxidative stress in type 2 diabetes mellitus and methods for its correction. Probl. Endokrinol. 2011;57(6):52-56. Russian.CrossRefGoogle Scholar
  2. 2.
    Azarova I, Bushueva O, Konoplya A, Polonikov A. Glutathione S-transferase genes and the risk of type 2 diabetes mellitus: Role of sexual dimorphism, gene-gene and genesmoking interactions in disease susceptibility. J. Diabetes. 2018;10(5):398-407.CrossRefGoogle Scholar
  3. 3.
    Christodoulou MI, Avgeris M, Kokkinopoulou I, Maratou E, Mitrou P, Kontos CK, Pappas E, Boutati E, Scorilas A, Fragoulis EG. Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk. Sci. Rep. 2019;9(1). ID 1512. doi: 10.1038/s41598-018-37856-1Google Scholar
  4. 4.
    Cook JP, Morris AP. Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. Eur. J. Hum. Genet. 2016;24(8):1175-1180.CrossRefGoogle Scholar
  5. 5.
    Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. IGF2BP2/IMP2-deficient mice resist obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding mitochondrial proteins. Cell Metab. 2015;21(4):609-621.CrossRefGoogle Scholar
  6. 6.
    Green MR, Sambrook J. Isolation of high-molecular-weight DNA using organic solvents. Cold Spring Harb. Protoc. 2017;2017(4). pdb.prot093450. doi: CrossRefGoogle Scholar
  7. 7.
    Hu Y, Zong G, Liu G, Wang M, Rosner B, Pan A, Willett WC, Manson JE, Hu FB, Sun Q. Smoking cessation, weight change, type 2 diabetes, and mortality. N. Engl. J. Med. 2018;379(7):623-632.CrossRefGoogle Scholar
  8. 8.
    Ishikawa S, Matsumura K, Kitamura N, Takanami Y, Ito S. Multi-omics analysis: Repeated exposure of a 3D bronchial tissue culture to whole-cigarette smoke. Toxicol. In Vitro. 2019;54:251-262.CrossRefGoogle Scholar
  9. 9.
    Langenberg C, Lotta LA. Genomic insights into the causes of type 2 diabetes. Lancet. 2018;391:2463-2474.CrossRefGoogle Scholar
  10. 10.
    Livingstone C, Borai A. Insulin-like growth factor-II: its role in metabolic and endocrine disease. Clin. Endocrinol. 2014;80(6):773-781.CrossRefGoogle Scholar
  11. 11.
    Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GC. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One. 2010;5(7). ID e11499. doi: CrossRefGoogle Scholar
  12. 12.
    Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macías H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordoñez-Sánchez ML, Rodríguez-Guillen R, Rodríguez-Torres M, Segura-Kato Y, García-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonàs-Guarch S, Hartl C, Ripke S; Diabetes Prevention Program Research Group, Tooley K, Lane J, Zerrweck C, Martínez-Hernández A, Córdova EJ, Mendoza-Caamal E, Contreras-Cubas C, González-Villalpando ME, Cruz-Bautista I, Muñoz-Hernández L, Gómez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M; Broad Genomics Platform, Gabriel S; DM2-GENES Consortium, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, González-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusié-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC; SIGMA DM2 Genetics Consortium. A loss-of-function splice acceptor variant in IGF2 is protective for type 2 diabetes. Diabetes. 2017;66(11):2903-2914.CrossRefGoogle Scholar
  13. 13.
    Pan A, Wang Y, Talaei M, Hu FB, Wu T. Relation of active, passive, and quitting smoking with incident type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2015;3(12):958-967.CrossRefGoogle Scholar
  14. 14.
    World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva, 1999.Google Scholar
  15. 15.
    World Health Organization. Global report on diabetes: executive summary (No. WHO/NMH/NVI/16.3). World Health Organization, 2016.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • I. E. Azarova
    • 1
    Email author
  • E. Yu. Klyosova
    • 1
  • V. A. Lazarenko
    • 1
  • A. I. Konoplya
    • 1
  • A. V. Polonikov
    • 1
  1. 1.Kursk State Medical University, Ministry of Health of the Russian FederationKurskRussia

Personalised recommendations