Modeling of Focal Seizures with Automatisms in Rats with Pendulum Movements
Phenotypical study was carried out in rats with pendulum movements. The animals exhibited a high level of abortive seizures in response to audiogenic stimuli and longer postictal catalepsy in comparison with those in Wistar population. Seizure severity positively correlated with the duration of poststimulus catalepsy (r=0.90). High aggressiveness towards humans, the absence of BP elevation in stress, lower body weights, and lower weights of the kidneys and spleen in PM rats are considered concomitant traits. Correlations were detected between startle-1 and BP in rats with pendulum movements (r=0.70) and between startle-10 and BP in narcotized Wistar rats (r=-0.0.71). The newly described signs in rats with pendulum movements did not contradict the signs of the focal seizure model with typical automatisms in humans.
Key Wordspendulum movements seizure blood pressure heart and kidney weights
Unable to display preview. Download preview PDF.
- 1.Akulov AE, Alekhina TA, Meshkov IO, Petrovskii ED, Prokudina OI, Koptyug IV, Savelov AA, Moshkin MP. Selection for catatonic type of reaction in rats: MRI analysis of the interline differences. Zh. Vyssh. Nerv. Deyat. 2014;64(4):439-447. Russian.Google Scholar
- 2.Alekhina TA, Prokudina OI, Ryazanova MA, Ukolova TN, Barykina NN, Kolpakov VG. Typological characteristics of behavior in strains of rats bred for enhancement and absence of pendulum movements. Association with brain monoamines. Zh. Vyssh. Nerv. Deyat. 2007;57(3):336-343. Russian.Google Scholar
- 3.Fedotova IB, Surina NM, Malikova LA, Raevsky KS, Poleteva II. Analysis of changes in muscle tone (catalepsy) occurring in rats after an audiogenic seizure. Zh. Vyssh. Nerv. Deyat. 2008;58(5):620-627. Russian.Google Scholar
- 5.Faingold CL. Brainstem networks: reticulo-cortical synchronization in generalized convulsive seizures. Jasper’s Basic Mechanisms of the Epilepsies. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds. Bethesda, 2012. P. 371-391.Google Scholar
- 8.Plyusnina IZ, Oskina IN, Tibeikina MA, Popova NK. Cross-fostering effects on weight, exploratory activity, acoustic startle reflex and corticosterone stress response in Norway gray rats selected for elimination and for enhancement of aggressiveness towards human. Behav. Genet. 2009;39(2):202-212.CrossRefGoogle Scholar