Modeling of Focal Seizures with Automatisms in Rats with Pendulum Movements

  • T. A. AlekhinaEmail author
  • R. V. Kozhemyakina

Phenotypical study was carried out in rats with pendulum movements. The animals exhibited a high level of abortive seizures in response to audiogenic stimuli and longer postictal catalepsy in comparison with those in Wistar population. Seizure severity positively correlated with the duration of poststimulus catalepsy (r=0.90). High aggressiveness towards humans, the absence of BP elevation in stress, lower body weights, and lower weights of the kidneys and spleen in PM rats are considered concomitant traits. Correlations were detected between startle-1 and BP in rats with pendulum movements (r=0.70) and between startle-10 and BP in narcotized Wistar rats (r=-0.0.71). The newly described signs in rats with pendulum movements did not contradict the signs of the focal seizure model with typical automatisms in humans.

Key Words

pendulum movements seizure blood pressure heart and kidney weights 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Akulov AE, Alekhina TA, Meshkov IO, Petrovskii ED, Prokudina OI, Koptyug IV, Savelov AA, Moshkin MP. Selection for catatonic type of reaction in rats: MRI analysis of the interline differences. Zh. Vyssh. Nerv. Deyat. 2014;64(4):439-447. Russian.Google Scholar
  2. 2.
    Alekhina TA, Prokudina OI, Ryazanova MA, Ukolova TN, Barykina NN, Kolpakov VG. Typological characteristics of behavior in strains of rats bred for enhancement and absence of pendulum movements. Association with brain monoamines. Zh. Vyssh. Nerv. Deyat. 2007;57(3):336-343. Russian.Google Scholar
  3. 3.
    Fedotova IB, Surina NM, Malikova LA, Raevsky KS, Poleteva II. Analysis of changes in muscle tone (catalepsy) occurring in rats after an audiogenic seizure. Zh. Vyssh. Nerv. Deyat. 2008;58(5):620-627. Russian.Google Scholar
  4. 4.
    Botion LM, Doretto MC. Changes in peripheral energy metabolism during audiogenic seizures in rats. Physiol. Behav. 2003;78(4-5):535-541.CrossRefGoogle Scholar
  5. 5.
    Faingold CL. Brainstem networks: reticulo-cortical synchronization in generalized convulsive seizures. Jasper’s Basic Mechanisms of the Epilepsies. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds. Bethesda, 2012. P. 371-391.Google Scholar
  6. 6.
    Hampel KG, Jahanbekam A, Elger CE, Surges R. Seizure-related modulation of systemic arterial blood pressure in focal epilepsy. Epilepsia. 2016;57(10):1709-1718.CrossRefGoogle Scholar
  7. 7.
    Heinrichs SC, Seyfried TN. Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms. Epilepsy Behav. 2006;8(1):5-38.CrossRefGoogle Scholar
  8. 8.
    Plyusnina IZ, Oskina IN, Tibeikina MA, Popova NK. Cross-fostering effects on weight, exploratory activity, acoustic startle reflex and corticosterone stress response in Norway gray rats selected for elimination and for enhancement of aggressiveness towards human. Behav. Genet. 2009;39(2):202-212.CrossRefGoogle Scholar
  9. 9.
    Poletaeva II, Surina NM, Kostina ZA, Perepelkina OV, Fedotova IB. The Krushinsky-Molodkina rat strain: the study of audiogenic epilepsy for 65 years. Epilepsy Behav. 2017;71(Pt B):130-141.CrossRefGoogle Scholar
  10. 10.
    Trimble M. Treatment issues for personality disorders in epilepsy. Epilepsy. 2013;54(Suppl. 1):41-45.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Evolutional Genetics, Federal Research Center Institute of Cytology and GeneticsSiberian Division of the Russian Academy of SciencesNovosibirskRussia

Personalised recommendations