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Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 2, pp 285–290 | Cite as

Ultrastructural Organization of Uveal Melanoma Stromal Cells

  • N. P. BgatovaEmail author
  • V. V. Makarova
  • Yu. S. Taskaeva
  • S. R. Nogovitsina
  • I. A. Toporkov
  • A. V. Eremina
  • A. N. Trunov
  • V. V. Chernykh
Article

Typical blood capillaries and vessels in uveal melanoma were shown and different types of uveal melanoma stromal cells were determined by electron microscopy and immunohistochemical analysis. Macrophages, fibroblasts of varying degrees of differentiation and endothelial-like cells with numerous caveolae in the cytoplasm were found in the channels of the extracellular matrix surrounding accumulations of tumor cells. The presence local structures positively stained for markers of the blood and lymphatic vessels (CD31 and podoplanin) in channels of the extracellular matrix suggests that the described endothelial-like cells can be the structural basis for blood and lymphatic vessels of the tumor.

Key Words

uveal melanoma fibroblasts endothelial-like cells 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • N. P. Bgatova
    • 1
    Email author
  • V. V. Makarova
    • 1
  • Yu. S. Taskaeva
    • 1
  • S. R. Nogovitsina
    • 1
  • I. A. Toporkov
    • 2
  • A. V. Eremina
    • 2
  • A. N. Trunov
    • 2
  • V. V. Chernykh
    • 2
  1. 1.Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of SciencesNovosibirskRussia
  2. 2.S. N. Fyodorov Federal State Institution National Medical Research Center Intersectoral Research and Technology Complex “Eye Microsurgery” Ministry of Health of the Russian Federation, Novosibirsk BranchNovosibirskRussia

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