Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 2, pp 224–228 | Cite as

p-Tyrosol Enhances the Production of New Neurons in the Hippocampal CA1 Field after Transient Global Cerebral Ischemia in Rats

  • M. Yu. KhodanovichEmail author
  • A. A. Kisel’
  • G. A. Chernysheva
  • V. I. Smol’yakova
  • M. S. Kudabaeva
  • E. P. Krutenkova
  • Ya. А. Tyumentseva
  • M. B. Plotnikov
Article
  • 9 Downloads

This study aimed at assessing the regenerative effect of p-tyrosol in transient global cerebral ischemia modeled in adult male Wistar rats by reversible occlusion of the three major vessels originating from the aortic arch and supplying the blood to the brain. p-Tyrosol was administered intraperitoneally in a dose of 20 mg/kg over 10 days after surgery. The death of NeuN+ mature neurons and the number of newly formed DCX+ neurons were assessed in the CA1 field of the hippocampus that is highly susceptible to damage in this model. We found that ischemia induced death of more than 50% mature neurons in the hippocampal CA1 field (p<0.001). p-Tyrosol stimulated the formation and growth of new neurons in the normally non-proliferative CA1 region of the hippocampus (p<0.05) and produced a neuroprotective effect on mature neurons (p<0.01).

Key Words

neurogenesis transient global cerebral ischemia p-tyrosol hippocampus CA1 field 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 2002;8(9):963-970.CrossRefGoogle Scholar
  2. 2.
    Atochin DN, Chernysheva GA, Smolyakova VI, Osipenko AN, Logvinov SV, Zhdankina AA, Sysolyatin SV, Kryukov YA, Anfinogenova Y, Plotnikova TM, Plotnikov MB. Neuroprotec tive effects of p-tyrosol after the global cerebral ischemia in rats. Phytomedicine. 2016;23(7):784-792.CrossRefGoogle Scholar
  3. 3.
    Bu Y, Rho S, Kim J, Kim MY, Lee DH, Kim SY, Choi H, Kim H. Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neurosci. Lett. 2007;414(3):218-221.CrossRefGoogle Scholar
  4. 4.
    Cayre M, Canoll P, Goldman J.E. Cell migration in the normal and pathological postnatal mammalian brain. Prog. Neurobiol. 2009;88(1):41-63.CrossRefGoogle Scholar
  5. 5.
    Chernysheva GA, Smol’yakova VI, Osipenko AN, Plotnikov MB. Evaluation of survival and neurological deficit in rats in the new model of global transient cerebral ischemia. Bull. Exp. Biol. Med. 2014;158(2):197-119.CrossRefGoogle Scholar
  6. 6.
    Di Benedetto R, Varì R, Scazzocchio B, Filesi C, Santangelo C, Giovannini C, Matarrese P, D’Archivio M, Masella R. Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness. Nutr. Metab. Cardiovasc. Dis. 2007;17(7):535-545.CrossRefGoogle Scholar
  7. 7.
    Kee NJ, Preston E, Wojtowicz JM. Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat. Exp. Brain Res. 2001;136(3):313-320.CrossRefGoogle Scholar
  8. 8.
    Khodanovich MY, Kisel’ AA, Chernysheva GA, Smol’yakova VI, Savchenko RR, Plotnikov MB. Effect of fluoxetine on neurogenesis in hippocampal dentate gyrus after global transient cerebral ischemia in rats. Bull. Exp. Biol. Med. 2016;161(3):351-354.CrossRefGoogle Scholar
  9. 9.
    Khodanovich M, Kisel A, Kudabaeva M, Chernysheva G, Smolyakova V, Krutenkova E, Wasserlauf I, Plotnikov M, Yarnykh V. Effects of fluoxetine on hippocampal neurogenesis and neuroprotection in the model of global cerebral ischemia in rats. Int. J. Mol. Sci. 2018;19(1). pii: E162. doi:  https://doi.org/10.3390/ijms19010162 CrossRefGoogle Scholar
  10. 10.
    Lin R, Cai J, Nathan C, Wei X, Schleidt S, Rosenwasser R, Iacovitti L. Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. Neurobiol. Dis. 2015;74:229-239.CrossRefGoogle Scholar
  11. 11.
    Liu J, Solway K, Messing RO, Sharp FR. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 1998;18(19):7768-7778.CrossRefGoogle Scholar
  12. 12.
    McGraw CP. Experimental cerebral infarctioneffects of pentobarbital in Mongolian gerbils. Arch. Neurol. 1977;34(6):334-336.CrossRefGoogle Scholar
  13. 13.
    Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 2002;110(4):429-441.CrossRefGoogle Scholar
  14. 14.
    St-Laurent-Thibault C, Arseneault M, Longpré F, Ramassamy C. Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid- β-induced toxicity. Involvement of the NF-κB signaling. Curr. Alzheimer. Res. 2011;8(5):543-551.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • M. Yu. Khodanovich
    • 1
    Email author
  • A. A. Kisel’
    • 1
  • G. A. Chernysheva
    • 2
  • V. I. Smol’yakova
    • 2
  • M. S. Kudabaeva
    • 1
  • E. P. Krutenkova
    • 1
  • Ya. А. Tyumentseva
    • 1
  • M. B. Plotnikov
    • 2
  1. 1.Laboratory of Neurobiology, Research Institute of Biology and BiophysicsTomsk State UniversityTomskRussia
  2. 2.Laboratory of Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

Personalised recommendations