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Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 1, pp 41–44 | Cite as

Modification of Biochemical Properties of Nitrosothiol by Fe3+ Cation: A Presumable Physiological Role

  • V. Yu. TitovEmail author
  • A. N. Osipov
  • L. G. Ibragimova
  • V. A. Petrov
  • A. M. Dolgorukova
Article
  • 7 Downloads

In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a “sulfhydric poison” Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are characteristic of dinitrosyl-iron complexes containing ferrous iron and thiols (DNIC/RSH). Since the potency to inhibit catalase results from the presence of -NO group, its loss in the presence of hemoglobin relates probably to transfer of this group to hemoglobin. The nitrosothiols are relatively stable compounds, so their ability to release NO under the action of iron chelators, which is characteristic of DNIC/RSH, can have important physiological implications, because the role of such chelators can be played by some endogenous agents as well. Thus, release of NO from the donor compounds can be controlled and regulated. Probably, the agents such as nitrosothiol+Fe3+ are the major constituents in the pool of nitroso compounds.

Key Words

nitric oxide (NO) dinitrosyl-iron (II) complex with thiolate ligands (DNIC/RSH) S-nitrosoglutathione (GSNO) Fe3+ cation 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. Yu. Titov
    • 1
    • 2
    Email author
  • A. N. Osipov
    • 1
  • L. G. Ibragimova
    • 1
  • V. A. Petrov
    • 1
  • A. M. Dolgorukova
    • 2
  1. 1.N. I. Pirogov Russian National Research Medical UniversityMinistry of Health of the Russian FederationMoscowRussia
  2. 2.Federal Research Center — All-Russian Research and Technology Institute for Poultry IndustryRussian Academy of SciencesSergiev PosadRussia

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