Participation of GABAB Receptors of Parafacial Respiratory Group in the Regulation of Respiration in Rats
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The respiratory effects of microinjections of baclofen and 2-hydroxysaclofen into the parafacial respiratory group were studied in experiments on rats. It was shown that activation of GABAB receptors of the parafacial respiratory group suppressed external respiration due to a decrease in the tidal volume and inspiratory flow rate. In parallel, we observed a decrease in the amplitude and an increase in the duration of inspiratory bursts of the diaphragm. Injection of GABAB receptor blocker into the parafacial respiratory group increased pulmonary ventilation due to an increase in volumetric parameters of the inspiratory phase. This effect was accompanied by prolongation of expiration and lengthening of the intervals between the inspiratory bursts of the diaphragm. These results suggest that GABAB receptors of the parafacial respiratory group are an important element of the central mechanisms regulating the volumetric respiratory parameters and are involved in the regulation of the phases of the respiratory cycle.
Key Wordsparafacial respiratory group pattern of breathing GABAB receptors baclofen 2-hydroxysaclofen
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- 1.Vedyasova OA, Manshina NG, Safonov VA, Tarakanov IA. Respiratory reactions to microinjections of GABA and baclofen into the Botzinger complex and the pre-Botzinger complex in rats. Ross. Fiziol. Zh. I. M. Sechenova. 2012;98(5):618-626. Russian.Google Scholar