Bulletin of Experimental Biology and Medicine

, Volume 168, Issue 1, pp 24–27 | Cite as

Participation of GABAB Receptors of Parafacial Respiratory Group in the Regulation of Respiration in Rats

  • T. E. Kovaleva
  • O. A. VedyasovaEmail author

The respiratory effects of microinjections of baclofen and 2-hydroxysaclofen into the parafacial respiratory group were studied in experiments on rats. It was shown that activation of GABAB receptors of the parafacial respiratory group suppressed external respiration due to a decrease in the tidal volume and inspiratory flow rate. In parallel, we observed a decrease in the amplitude and an increase in the duration of inspiratory bursts of the diaphragm. Injection of GABAB receptor blocker into the parafacial respiratory group increased pulmonary ventilation due to an increase in volumetric parameters of the inspiratory phase. This effect was accompanied by prolongation of expiration and lengthening of the intervals between the inspiratory bursts of the diaphragm. These results suggest that GABAB receptors of the parafacial respiratory group are an important element of the central mechanisms regulating the volumetric respiratory parameters and are involved in the regulation of the phases of the respiratory cycle.

Key Words

parafacial respiratory group pattern of breathing GABAB receptors baclofen 2-hydroxysaclofen 


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  1. 1.
    Vedyasova OA, Manshina NG, Safonov VA, Tarakanov IA. Respiratory reactions to microinjections of GABA and baclofen into the Botzinger complex and the pre-Botzinger complex in rats. Ross. Fiziol. Zh. I. M. Sechenova. 2012;98(5):618-626. Russian.Google Scholar
  2. 2.
    Bochorishvili G, Stornetta RL, Coates MB, Guyenet PG. Pre-Bötzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons. J. Comp. Neurol. 2012;520(5):1047-1061.CrossRefGoogle Scholar
  3. 3.
    Bongianni F, Mutolo D, Cinelli E, Pantaleo T. Respiratory responses induced by blockades of GABA and glycine receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit. Brain Res. 2010;1344:134-147.CrossRefGoogle Scholar
  4. 4.
    Boutin RC, Alsahafi Z, Pagliardini S. Cholinergic modulation of the parafacial respiratory group. J. Physiol. 2017;595(4):1377-1392.CrossRefGoogle Scholar
  5. 5.
    Fortuna MG, West GH, Stornetta RL, Guyenet PG. Bötzinger expiratory-augmenting neurons and the parafacial respiratory group. J. Neurosci. 2008;28(10):2506-2515.CrossRefGoogle Scholar
  6. 6.
    Huckstepp RT, Cardoza KP, Henderson LE, Feldman JL. Role of parafacial nuclei in control of breathing in adult rats. J. Neurosci. 2015;35(3):1052-1067.CrossRefGoogle Scholar
  7. 7.
    Onimaru H, Ikeda K, Kawakami K. Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis. Respir. Physiol. Neurobiol. 2009;168:13-18.CrossRefGoogle Scholar
  8. 8.
    Pagliardini S, Janczewski WA., Tan W, Dickson CT, Deisseroth K, Feldman JL. Active expiration induced by excitation of ventral medulla of adult anesthetized rats. J. Neurosci. 2011;31(8):2895-2905.CrossRefGoogle Scholar
  9. 9.
    Sun H, Ma C, Kelly J, Wu S. GABAB receptor-mediated presynaptic inhibition of glutamatergic transmission in the inferior colliculus. Neurosci. Lett. 2006;399:151-156.CrossRefGoogle Scholar
  10. 10.
    Vedyasova OA, Kovaleva TE. Role of GABAA receptors of parafacial respiratory group in control of respiration in rats. Bull. Exp. Biol. Med. 2018;165(6):711-714.CrossRefGoogle Scholar
  11. 11.
    Wang HY, Kuo ZC, Fu YS, Chen RF, Min MY, Yang HW. BAB receptor-mediated tonic inhibition regulates the spontaneousfiring of locus coeruleus neurons in developing rats and in citalopram-treated rats. J. Physiol. 2015;593(1):161-180.CrossRefGoogle Scholar
  12. 12.
    Zhang W, Barnbrock A, Gajic S. Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse. J. Physiol. 2002;540:435-446.CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Samara National Research UniversitySamaraRussia

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