Hepatic Mast Cells in Mice with Experimental Amyloidosis
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We studied the response of mast cells in mouse liver to experimental amyloidosis modeled by administration of aqueous solution of soy cream substitute and its correction by spontaneous dry red wine intake per os. Mast cells in mice with amyloidosis and intact mice were presented by α-ortho- and β1-metachromatic non-degranulating forms. In mice with amyloidosis, the relative content of β1-metachromatic mast cells in the capsule and parenchyma of the liver was by 1.8 and 1.5 times higher than in intact animals, respectively. In mice with amyloidosis receiving dry red wine, the proportions of mast cells with different degrees of metachromasy and degranulation were similar to those in intact mice, but the relative content of β1-metachromatic mast cells in the liver parenchyma in these animals was by 1.6 times higher than in intact mice. Therefore, mast cells respond to amyloidosis development by changes in both the metachromasy and degranulation degree; dry red wine can be considered as a factor of amyloidosis prevention.
Key Wordsmice red wine liver mast cells experimental amyloidosis
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- 1.Baglay EO, Dubikov AI. Mast cells are key participants in thepathogenesis of immunoinflammatory diseases. Nauch.-Prakt. Revmat. 2015;53(2):182-189. Russian.Google Scholar
- 2.Gordon DS. Tinctorial parallels of mast cells. Macro- and Microstructure of Tissues in the Norm, Pathology, and Experiment. Cheboksary, 1981. P. 97-101. Russian.Google Scholar
- 3.Kozlov VA, Busova OS. Mast cell migration in kidney. Vestn. Chuvash. Gos. Ped. Univer. im. I.Ya.Yakovleva. 2010;(1):40-45. Russian.Google Scholar
- 5.Lindner DP, Poberin IA, Rozkin MYa, Efimov VS. Morphometric analysis of populations of mast cells. Arkh. Patol. 1980;42(6):60-64. Russian.Google Scholar