Effect of the Hemoxygenase—Carbon Monoxide (HO—CO) System on the Reactivity of Uterine Artery Branches in Rats
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First to fourth-order branches of the uterine artery in sexually mature female Wistar rats were studied by biomicroscopy. After administration of a CO donor hemin (60 mM), the diameters of large uterine branches with a well-developed muscle layer markedly increased, while the increase in diameter of small vessels with one often interrupted layer of smooth muscle cells increased insignificantly. Zinc protoporphyrin IX (30 mM) in all cases blocked this effect. However, zinc protoporphyrin IX does not affect NO-mediated reaction of the branches of the uterine artery caused by administration of L-arginine (60 mM), and L-NAME did not significantly affect reactivity of uterine artery branches associated with the hemoxygenase—CO system. In contrast to NO, CO produced less potent and rapid, but more sustained effect. The target for the hemoxygenase—CO system is mainly arteries with developed muscular layer, while the target for the NO synthase—NO is small vessels where endothelium plays a Rdecisive role in the regulation of vasomotor reactions.
Key Wordsbiomicroscopy hemoxygenase—carbon monoxide first to third-order branches of the uterine artery donors and blockers of CO generation
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- 5.Chertok VM, Nemkov YuK, Chertok AG. Intraorgan vasculature of the uterus. Vladivostok, 2018. Russian.Google Scholar