Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 801–804 | Cite as

Histotopography of α-Gustdusin- and T2R3-Expressing Lymphocytes in Mouse Spleen

  • I. A. Cherenkov
  • V. G. SergeyevEmail author
  • D. B. Nikityuk
  • V. M. Chychkov

Histotopography of lymphocytes expressing bitter taste receptors of T2R family and α-gustducin (receptor-associated subunit of the G-protein complex) in mouse spleen in the norm and in 48 h after intraperitoneal administration of LPS was studied by the immunohistochemical method. Two populations of immunopositive lymphocytes expressing the above proteins were detected in the spleen; they were located in the marginal zones of lymphoid follicles and periarteriolar lymphoid sheaths. In most α-gustducin-positive lymphocytes, co-expression of α-gustducin and CD19 (B-cell marker) was found. Intraperitoneal administration of LPS significantly increased the number of gustducinergic lymphocytes in periarteriolar lymphoid sheaths. We hypothesize that spleen lymphocytes with gustducin signaling are involved in T-dependent immune response to the blood bacterial polysaccharides.

Key Words

T2R3 receptor α-gustducin spleen lymphocytes 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • I. A. Cherenkov
    • 1
  • V. G. Sergeyev
    • 1
    Email author
  • D. B. Nikityuk
    • 2
  • V. M. Chychkov
    • 1
  1. 1.Udmurt State UniversityIzhevskRussia
  2. 2.Federal Research Center of Nutrition, Biotechnology, and Food SafetyMoscowRussia

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