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Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 787–790 | Cite as

Myocardial Expression of SERCA2a and Structural and Functional Indices in Patients with Atrial Fibrillation

  • D. S. Kondrat’evaEmail author
  • S. A. Afanas’ev
  • E. A. Archakov
  • L. P. Tsapko
  • R. E. Batalov
EXPERIMENTAL METHODS FOR CLINICAL PRACTICE
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The study examined the relationships between SERCA2a expression in the myocardium and structural and functional indices in patients with atrial fibrillation. In uniform cohort of patients, this expression differed significantly but positively correlated with the size of the left atrium, end-systolic volume, and end-diastolic volume. In contrast, SERCA2a expression negatively correlated with early (peak E) and late (peak A) diastolic filling rates in left ventricle. SERCA2a expression was also associated with echocardiographic parameters reflecting structural and functional status of the heart in patients with persistent atrial fibrillation.

Key Words

atrial fibrillation SERCA2a expression echocardiography 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • D. S. Kondrat’eva
    • 1
    Email author
  • S. A. Afanas’ev
    • 1
  • E. A. Archakov
    • 1
  • L. P. Tsapko
    • 1
  • R. E. Batalov
    • 1
  1. 1.Research Institute of Cardiology, Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

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