Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 779–783 | Cite as

Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment

  • Yu. S. TaskaevaEmail author
  • N. P. Bgatova

Five cytological types of hepatocellular carcinoma-29 (G-29) grown in the muscle tissue of the thigh of experimental animals were identified by transmission electron microscopy; 89% of these were poorly differentiated type I-III cells. Lithium in a concentration of 20 mM produced a damaging effect on poorly differentiated G-29 cells: the number of cells with zones of intracellular component destruction and volume density of these zones increased, while volume density of cisterns of endoplasmic reticulum decreased. These results suggest that lithium carbonate can cause destructive changes in the heterogeneous population of G-29 cells during in vivo tumor development.

Key Words

hepatocellular carcinoma lithium carbonate ultrastructural organization electron microscopy 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Research Institute of Clinical and Experimental Lymphology, Federal Research Center Institute of Cytology and GeneticsSiberian Division of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk National Research State UniversityNovosibirskRussia

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