Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 755–758 | Cite as

Effect of Apoptotic Neutrophils on the Production of Erythropoietin, MMP-9, and TIMP-1 in Cultures of Human Macrophages

  • L. V. SakhnoEmail author
  • E. Ya. Shevela
  • A. P. Lykov
  • O. V. Poveshchenko
  • A. A. Ostanin
  • E. R. Chernykh

We studied the effect of apoptotic neutrophils on the production of erythropoietin, MMP-9, and TIMP-1 by GM-CSF-induced human macrophages. GM-CSF-induced macrophages spontaneously produce erythropoietin and secrete MMP-9 and TIMP-1. Polarization of these macrophages towards the M2-like phenotype after exposure to apoptotic neutrophils considerably increased the production of erythropoietin; the MMP-9/TIMP-1 ratio tended to increase under these conditions due to a decrease in TIMP-1.

Key Words

human macrophages efferocytosis erythropoietin MMP-9 TIMP-1 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. V. Sakhno
    • 1
    Email author
  • E. Ya. Shevela
    • 1
  • A. P. Lykov
    • 2
  • O. V. Poveshchenko
    • 2
  • A. A. Ostanin
    • 1
  • E. R. Chernykh
    • 1
  1. 1.Research Institute of Fundamental and Clinical ImmunologyNovosibirskRussia
  2. 2.Research Institute of Clinical and Experimental LymphologyAffiliated Branch of Federal Research Center Institute of Cytology and GeneticsNovosibirskRussia

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