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Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 716–719 | Cite as

Effect of Neuropeptide Y on Action Potential of Working Right Atrial Cardiomyocytes in Early Postnatal Ontogeny

  • A. A Zverev
  • T. A. Anikina
  • N. G. Iskakov
  • A. L. Zefirov
  • T. L. ZefirovEmail author
Article
  • 8 Downloads

The effects of neuropeptide Y (10—9-10—6 M) on electrical activity of right atrial cardiomyocytes of rats aging 7, 21, and 100 days were examined in vitro. Neuropeptide Y affected the amplitude-temporal parameters of the action potential in these cells. It decreased the duration of repolarization phase in 7-day-old rats in concentrations of 10—8 and 10—7 M, in 21-day-old rats at 10—8 and 10—6 M, and in 100-day-old at 10—6 M. The data indicate elevation of total membrane potassium current under the action of neuropeptide Y.

Key Words

neuropeptide Y action potential membrane potential cardiomyocytes ontogeny 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. A Zverev
    • 1
  • T. A. Anikina
    • 1
  • N. G. Iskakov
    • 1
  • A. L. Zefirov
    • 2
  • T. L. Zefirov
    • 1
    Email author
  1. 1.Department of Human Health ProtectionKazan (Volga Region) Federal UniversityKazanRussia
  2. 2.Department of Normal Physiology, Kazan Federal Medical UniversityMinistry of Health of the Russian FederationKazanRussia

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