Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 6, pp 716–719 | Cite as

Effect of Neuropeptide Y on Action Potential of Working Right Atrial Cardiomyocytes in Early Postnatal Ontogeny

  • A. A Zverev
  • T. A. Anikina
  • N. G. Iskakov
  • A. L. Zefirov
  • T. L. ZefirovEmail author

The effects of neuropeptide Y (10—9-10—6 M) on electrical activity of right atrial cardiomyocytes of rats aging 7, 21, and 100 days were examined in vitro. Neuropeptide Y affected the amplitude-temporal parameters of the action potential in these cells. It decreased the duration of repolarization phase in 7-day-old rats in concentrations of 10—8 and 10—7 M, in 21-day-old rats at 10—8 and 10—6 M, and in 100-day-old at 10—6 M. The data indicate elevation of total membrane potassium current under the action of neuropeptide Y.

Key Words

neuropeptide Y action potential membrane potential cardiomyocytes ontogeny 


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  1. 1.
    Bryant SM, Hart G. Effects of neuropeptide Y on L-type calcium current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 1996;118(6):1455-1460.CrossRefGoogle Scholar
  2. 2.
    Bell D, Allen AR, Kelso EJ, Balasubramaniam A, McDermott BJ. Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure. J. Pharmacol. Exper. Ther. 2002;303(2):581-591.CrossRefGoogle Scholar
  3. 3.
    Duarte-Neves J, Pereira de Almeida L, Cavadas C. Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases. Neurobiol. Dis. 2016;95:210-224.CrossRefGoogle Scholar
  4. 4.
    Gøtzsche CR, Woldbye DP. The role of NPY in learning and memory. Neuropeptides, 2016;55:79-89.CrossRefGoogle Scholar
  5. 5.
    Hansel DE, Eipper BA, Ronnett GV. Neuropeptide Y functions as a neuroproliferative factor. Nature. 2001;410:940-944.CrossRefGoogle Scholar
  6. 6.
    Hirsch D, Zukowska Z. NPY and stress 30 years later: the peripheral view. Cell. Mol. Neurobiol. 2012 Vol. 32(5):645-659.CrossRefGoogle Scholar
  7. 7.
    Masliukov PM, Moiseev K, Emanuilov AI, Anikina TA, Zverev AA, Nozdrachev AD. Development of neuropeptide Y-mediated heart innervation in rats. Neuropeptides. 2016;55:47-54.CrossRefGoogle Scholar
  8. 8.
    McDermott BJ, Bell D. NPY and cardiac diseases. Curr. Top. Med. Chem. 2007;7(17):1692-1703.CrossRefGoogle Scholar
  9. 9.
    Protas L, Qu J, Robinson R.B. Neuropeptide Y: Neurotransmitter or Trophic Factor in the Heart? News Physiol. Sci. 2003; 18:181-185.PubMedGoogle Scholar
  10. 10.
    Zukowska-Grojec Z. Neuropeptide Y a novel sympathetic stress hormone and more. Ann N.Y. Acad. Sci. 1995;771:219-233.CrossRefGoogle Scholar
  11. 11.
    Zverev AA, Anikina TA, Iskakov NG, Zefirov AL, Zefirov TL. Effect of neuropeptide Y on action potential generation in working cardiomyocytes of the right atrium in rat heart. Bull. Exp. Biol. Med. 2018;165(5):610-612.CrossRefGoogle Scholar
  12. 12.
    Zverev AA, Anikina TA, Maslyukov PM, Zefirov TL. Role of Neuropeptide Y in myocardial contractility of rats during early postnatal ontogeny. Bull. Exp. Biol. Med. 2014;157(4):421-423.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. A Zverev
    • 1
  • T. A. Anikina
    • 1
  • N. G. Iskakov
    • 1
  • A. L. Zefirov
    • 2
  • T. L. Zefirov
    • 1
    Email author
  1. 1.Department of Human Health ProtectionKazan (Volga Region) Federal UniversityKazanRussia
  2. 2.Department of Normal Physiology, Kazan Federal Medical UniversityMinistry of Health of the Russian FederationKazanRussia

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