Bulletin of Experimental Biology and Medicine

, Volume 167, Issue 5, pp 663–666 | Cite as

Effect of Herbicide Glyphosate on Drosophila melanogaster Fertility and Lifespan

  • R. R. GalinEmail author
  • I. F. Akhtyamova
  • E. I. Pastukhova

We studied the effect of herbicide glyphosate on fertility and lifespan of D. melanogaster. Wild type flies obtained from the natural population and maintained in the laboratory and flies of the Oregon-R strain were used. Glyphosate concentrations 0.028, 0.28, and 2.8 mg/ml were tested. Glyphosate in a concentration of 2.8 mg/ml reduced lifespan of male flies and the number of pupae and imago in the progeny of D. melanogaster from natural population and Oregon-R strain, while the concentrations of 0.028 and 0.28 mg/ml produced no adverse effect on the studied parameters.

Key Words

herbicide glyphosate D. melanogaster 


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  1. 1.
    Belokon SV, Sklyar VS. Genetoxical effect of herbicides and fecundity of Drosophila melanogaster. Vestn. Odes. Nats. Univer. Biol. 2012;17(4):57-61. Ukrainian.Google Scholar
  2. 2.
    Kopytchuk TE, Belokon SV, Sechnyak OL. The influence of herbicides on Drosophila melanogaster viability. Vestn. Odes. Nats. Univer. Biol. 2011;16(6):47-51. Ukrainian.Google Scholar
  3. 3.
    Nedopitanska NM. The problem of the carcinogenic risk of glyphosate: new data. Such. Probl. Toksikol. 2011;(1-2):5-15. Ukrainian.Google Scholar
  4. 4.
    Benachour N, Séralini GE. Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. Chem. Res. Toxicol. 2009;22(1):97-105.CrossRefGoogle Scholar
  5. 5.
    de Aguiar LM, Figueira FH, Gottschalk MS, da Rosa CE. Glyphosate-based herbicide exposure causes antioxidant defence responses in the fruit fly Drosophila melanogaster. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016;185-186:94-101.Google Scholar
  6. 6.
    Kier LD, Kirkland DJ. Review of genotoxicity studies of glyphosate and glyphosate-based formulations. Crit. Rev. Toxicol. 2013;43(4):283-315.CrossRefGoogle Scholar
  7. 7.
    National pesticide information center. Glyphosate technical fact sheet. URL:
  8. 8.
    Richard S, Moslemi S, Sipahutar H, Benachour N, Seralini G. E. Differential effects of glyphosate and roundup on human placental cells and aromatase. Environ. Health Perspect. 2005;113(6):716-720.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • R. R. Galin
    • 1
    Email author
  • I. F. Akhtyamova
    • 1
  • E. I. Pastukhova
    • 1
  1. 1.Chelyabinsk State UniversityChelyabinskRussia

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